Shc1 - SHC adaptor protein 1 Gene

Also Known as P66shc

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85385

Summary

Enables enzyme binding activity; epidermal growth factor receptor binding activity; and phosphotyrosine residue binding activity. Involved in several processes, including positive regulation of smooth muscle cell proliferation; positive regulation of vasoconstriction; and response to peptide hormone. Located in endosome membrane; nucleus; and plasma membrane. Part of Shc-EGFR complex. Used to study glomerulosclerosis. Biomarker of familial hyperlipidemia and hepatocellular carcinoma. Orthologous to human SHC1 (SHC adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Shc1 Products (2)

mRNA Protein Name
NM_001164060.2 NP_001157532.1 SHC-transforming protein 1 isoform a
NM_053517.3 NP_445969.2 SHC-transforming protein 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables epidermal growth factor receptor binding IPI
IPI: Inferred from physical interaction
7513704 RGD
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
8910399 RGD
enables phosphotyrosine residue binding IPI
IPI: Inferred from physical interaction
9271418 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11694516 RGD
enables protein phosphatase 2A binding IDA
IDA: Inferred from direct assay
11884620 RGD
enables protein phosphatase 2A binding IPI
IPI: Inferred from physical interaction
11884620 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
11884620 RGD
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
9582017 RGD
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
15262993 RGD
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
15067377 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
11884620 RGD
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
17925406 RGD
involved in insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
7513704 RGD
involved in neuron differentiation IMP
IMP: Inferred from mutant phenotype
17274988 RGD
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
15485499 RGD
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
15262993 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
7513704 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
12837289 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
16242150 RGD
involved in regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
27270176 RGD
involved in response to endothelin IMP
IMP: Inferred from mutant phenotype
27270176 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
10612430 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
16699171 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
16439820 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
11954667 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
17068140 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16699171 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
16699171 RGD
Cellular Component GO Annotation Evidence References Source
part of Shc-EGFR complex IDA
IDA: Inferred from direct assay
7513704 RGD
located in endosome membrane IDA
IDA: Inferred from direct assay
17363458 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SHC-transforming protein 1

  • SH2 domain protein C1

  • SHC (Src homology 2 domain containing) transforming protein 1

  • src homology 2 domain-containing-transforming protein C1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12856 SHC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21432 Shc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27950 Shc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Shc1 NCBI NCBI:6464