Prkcq - protein kinase C, theta Gene

Also Known as Pkcq

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85420

About Prkcq

Primary_assembly 17: 67,246,394-67,378,704 reverse strand.mRatBN7.2:CM026990.1

This gene has 2 transcripts (splice variants), 204 orthologues, 5 paralogues and is associated with 12 phenotypes. Biased expression in Thymus (RPKM 276.), Muscle (RPKM 269.6) and 7 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cellular component biogenesis; positive regulation of protein transport; and response to glucose. Located in several cellular components, including neuromuscular junction; nucleus; and sarcolemma. Biomarker of hyperinsulinism and prostate adenocarcinoma. Orthologous to human PRKCQ (protein kinase C theta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcq Products (2)

mRNA Protein Name
NM_001276721.1 NP_001263650.1 protein kinase C theta type
NM_001276721.1 NP_001263650.1 protein kinase C theta type

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11698413 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12697665 RGD
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
12697665 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
10944456 RGD
involved in positive regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
9353339 RGD
involved in positive regulation of protein import into nucleus IMP
IMP: Inferred from mutant phenotype
12697665 RGD
involved in positive regulation of protein secretion IDA
IDA: Inferred from direct assay
11095914 RGD
involved in positive regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
9353339 RGD
involved in regulation of G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
9353339 RGD
involved in regulation of vasoconstriction IEP
IEP: Inferred from expression pattern
16951045 RGD
involved in respiratory burst IEP
IEP: Inferred from expression pattern
10218646 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
11914741 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
15994856 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
7755564 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
11404218 RGD
involved in tissue regeneration IEP
IEP: Inferred from expression pattern
12007632 RGD
Cellular Component GO Annotation Evidence References Source
located in neuromuscular junction IDA
IDA: Inferred from direct assay
7738116 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
7738116 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkcq Protein Structure

C1_nPKC_theta-like_rpt1

C1_nPKC_theta-like_rpt1: cd20834 (152 - 212)

C1_nPKC_theta-like_rpt2

C1_nPKC_theta-like_rpt2: cd20837 (231 - 280)

STKc_nPKC_theta

STKc_nPKC_theta: cd05619 (373 - 703)

  • 0
  • 200
  • 400
  • 600
  • 707 a.a.
Protein Preferred Names Protein Names

protein kinase C theta type

  • nPKC-theta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11137 PRKCQ Human Pre-designed siRNA Set A / Unkown
HY-RS11138 Prkcq Mouse Pre-designed siRNA Set A / Unkown
HY-RS11139 Prkcq Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkcq NCBI NCBI:5588