Prkd1 - protein kinase D1 Gene

Also Known as Pkcm; Prkcm; nPKC-D1; nPKC-mu

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85421

About Prkd1

Primary_assembly 6: 67,725,905-68,039,042 reverse strand.mRatBN7.2:CM026979.1

This gene has 3 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 8 phenotypes. Biased expression in Kidney (RPKM 52.3), Heart (RPKM 33.2) and 8 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in intracellular signal transduction. Predicted to be located in several cellular components, including autophagosome membrane; cell-cell junction; and trans-Golgi network. Orthologous to human PRKD1 (protein kinase D1). [provided by Alliance of Genome Resources, Apr 2022]

Prkd1 Products (2)

mRNA Protein Name
NM_001412095.1 NP_001399024.1 serine/threonine-protein kinase D1 isoform 2
NM_001276715.2 NP_001263644.1 serine/threonine-protein kinase D1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
25889640 RGD
enables protein kinase C binding IPI
IPI: Inferred from physical interaction
15652511 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
16648482 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12057008 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to angiotensin IDA
IDA: Inferred from direct assay
15652511 RGD
involved in cellular response to endothelin IDA
IDA: Inferred from direct assay
15652511 RGD
involved in cellular response to norepinephrine stimulus IDA
IDA: Inferred from direct assay
15652511 RGD
involved in cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
16648482 RGD
involved in cellular response to organic cyclic compound IMP
IMP: Inferred from mutant phenotype
25889640 RGD
involved in cellular response to phorbol 13-acetate 12-myristate IDA
IDA: Inferred from direct assay
15652511 RGD
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
12057008 RGD
involved in positive regulation of cell size IMP
IMP: Inferred from mutant phenotype
16648482 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25889640 RGD
involved in positive regulation of peptide hormone secretion IMP
IMP: Inferred from mutant phenotype
16648482 RGD
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
21041300 RGD
involved in positive regulation of protein export from nucleus IMP
IMP: Inferred from mutant phenotype
16648482 RGD
involved in positive regulation of sarcomere organization IMP
IMP: Inferred from mutant phenotype
16648482 RGD
involved in regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril IMP
IMP: Inferred from mutant phenotype
21041300 RGD
involved in response to norepinephrine IDA
IDA: Inferred from direct assay
16648482 RGD
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
15652511 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
25889640 RGD
located in membrane IDA
IDA: Inferred from direct assay
15652511 RGD
located in nucleus IDA
IDA: Inferred from direct assay
16648482 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15652511 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkd1 Protein Structure

C1_PKD1_rpt1

C1_PKD1_rpt1: cd20839 (137 - 208)

C1_PKD1_rpt2

C1_PKD1_rpt2: cd20842 (242 - 335)

PH_PKD

PH_PKD: cd01239 (421 - 548)

STKc_PKD

STKc_PKD: cd14082 (594 - 853)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 928 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase D1

  • protein kinase C mu type

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11144 PRKD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11145 Prkd1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS11146 Prkd1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkd1 NCBI NCBI:5587