CBR3 - carbonyl reductase 3 Gene

Also Known as hCBR3; SDR21C2; HEL-S-25

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 874

About CBR3

Cytogenetic location: 21q22.12 Genomic coordinates (GRCh38): 21:36,135,079-36,146,562 (from NCBI)

This gene has 1 transcript (splice variant), 503 orthologues and 13 paralogues. Ubiquitous expression in esophagus (RPKM 6.1), skin (RPKM 5.7) and 22 other tissues.

Summary

Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]

CBR3 Products (1)

mRNA Protein Name
NM_001236.4 NP_001227.1 carbonyl reductase [NADPH] 3

CBR3 Protein Structure

adh_short

adh_short: short chain dehydrogenase (7 - 147)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

carbonyl reductase [NADPH] 3

  • NADPH-dependent carbonyl reductase 3

CBR3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CBR3 O75828 BICD2 Homo sapiens Q8TD16-2
Validated Y2H
32296183
Intra
CBR3 O75828 BICD2 Homo sapiens Q8TD16-2
Y2H Prey Pooling
32296183
Intra
CBR3 O75828 BICD2 Homo sapiens Q8TD16-2
Y2H Array
32296183
Intra
CBR3 O75828 CBR1 Homo sapiens P16152
Anti Tag CoIP
33961781
Intra
CBR3 O75828 CBR1 Homo sapiens P16152
Anti Tag CoIP
28514442
Intra
CBR3 O75828 CBR1 Homo sapiens P16152
Anti Tag CoIP
26496610
Intra
CBR3 O75828 SDCBP Homo sapiens O00560
Y2H Array
25910212
Intra
CBR3 O75828 SDCBP Homo sapiens O00560
Validated Y2H
25910212
Intra
CBR3 O75828 SDCBP Homo sapiens O00560
Y2H Array
31515488
Intra
CBR3 O75828 SDCBP Homo sapiens O00560
Y2H Bait-Prey Pool
25910212
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CBR3 Proteins

Cat. No. Product Name Accession Purity
HY-P75605 CBR3 Protein, Human (His) O75828 (M1-W277) ≥ 95%, as determined by reducing SDS-PAGE.

CBR3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82650 CBR3 Antibody (YA2395) WB Human
HY-P82650A CBR3 Antibody (YA2395)(PBS only) WB Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS28634 Cbr3 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CBR3 MGD MGI:1309992
Bos taurus CBR3 VGNC VGNC:53516
Rattus norvegicus CBR3 RGD RGD:1309728
Canis familiaris CBR3 VGNC VGNC:38764
Felis catus CBR3 VGNC VGNC:102611
Others CBR3 NCBI