FBP2 - fructose-bisphosphatase 2 Gene

Also Known as CORLK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8789

About FBP2

Cytogenetic location: 9q22.32 Genomic coordinates (GRCh38): 9:94,558,720-94,593,824 (from NCBI)

This gene has 1 transcript (splice variant), 198 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in stomach (RPKM 15.5), esophagus (RPKM 4.0) and 3 other tissues.

Summary

This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008]

FBP2 Products (1)

mRNA	Protein	Name
NM_003837.4	NP_003828.2	fructose-1,6-bisphosphatase isozyme 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBP2 Protein Structure

FBPase

0
100
200
300
339 a.a.

Protein Preferred Names	Protein Names
fructose-1,6-bisphosphatase isozyme 2	D-fructose-1,6-bisphosphate 1-phosphohydrolase 2

FBP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FBP2	O00757	FBP1	Homo sapiens	P09467	Validated Y2H	25416956
Intra	FBP2	O00757	FBP1	Homo sapiens	P09467	Y2H Prey Pooling	32296183
Intra	FBP2	O00757	FBP1	Homo sapiens	P09467	Validated Y2H	32296183
Intra	FBP2	O00757	FBP1	Homo sapiens	P09467	Y2H Array	25416956
Intra	FBP2	O00757	FBP1	Homo sapiens	P09467	Anti Tag CoIP	33961781
Intra	FBP2	O00757	FBP1	Homo sapiens	P09467	Y2H Array	32296183
Intra	FBP2	O00757	FBP1	Homo sapiens	P09467	Anti Tag CoIP	28514442
Intra	FBP2	O00757	FBP1	Homo sapiens	P09467	Y2H Array	31515488
Intra	FBP2	O00757	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	FBP2	O00757	FBP2	Homo sapiens	O00757	Validated Y2H	32296183
Intra	FBP2	O00757	FBP2	Homo sapiens	O00757	Y2H Array	25416956
Intra	FBP2	O00757	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	FBP2	O00757	FBP2	Homo sapiens	O00757	Y2H Array	32296183
Intra	FBP2	O00757	FBP2	Homo sapiens	O00757	Y2H Prey Pooling	32296183
Intra	FBP2	O00757	FBP2	Homo sapiens	O00757	Y2H Array	31515488
Intra	FBP2	O00757	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

FBP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81519	FBP1 Antibody (YA1264)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Leukodystrophy, Childhood-Onset, Remitting	CORLK
Fructose-1,6-Bisphosphatase Deficiency	Fructose-1,6-Diphosphatase Deficiency Baker-Winegrad Disease FBP1D Fbpase Deficiency Fructose 1,6 Diphosphatase Deficiency Fructose 1 Phosphate Aldolase Deficiency Fbp1 Deficiency Hereditary Fructose Intolerance Syndrome
Glycogen Storage Disease	Glycogenosis Glycogenoses Gsd Storage Disease, Glycogen Gsd - [Glycogen Storage Disease] Glycogen Thesaurismosis Diffuse Glycogenosis Generalised Glycogen Storage Disease Generalised Glycogenosis Generalised Glycogen Storage Disease Of Infants Glycogen Synthase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07242	KHSRP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17537	Fbp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04780	FBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17201	Folr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17637	Fbp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18180	Khsrp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24097	Fbp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FBP2	VGNC	VGNC:62173
Rattus norvegicus	FBP2	RGD	RGD:620930
Macaca mulatta	FBP2	VGNC	VGNC:72626
Bos taurus	FBP2	VGNC	VGNC:28888
Canis familiaris	FBP2	VGNC	VGNC:49894
Mus musculus	FBP2	MGD	MGI:95491
Others	FBP2	NCBI