VNN1 - vanin 1 Gene

Also Known as HDLCQ8; Tiff66

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8876

About VNN1

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:132,680,849-132,714,055 (from NCBI)

This gene has 1 transcript (splice variant), 165 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in duodenum (RPKM 74.9), liver (RPKM 69.9) and 5 other tissues.

Summary

This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each Other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess Pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two Other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]

VNN1 Products (1)

mRNA Protein Name
NM_004666.3 NP_004657.2 pantetheinase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables pantetheine hydrolase activity IDA
IDA: Inferred from direct assay
11491533 GOA
Biological Process GO Annotation Evidence References Source
involved in pantothenate metabolic process IDA
IDA: Inferred from direct assay
11491533 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VNN1 Protein Structure

CN_hydrolase

CN_hydrolase: Carbon-nitrogen hydrolase (56 - 219)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 513 a.a.
Protein Preferred Names Protein Names

pantetheinase

  • pantetheine hydrolase

Recombinant VNN1 Proteins

Cat. No. Product Name Accession Purity
HY-P70502 Vanin-1 Protein, Human (HEK293, His) O95497 (Q22-S490) ≥ 95%, as determined by reducing SDS-PAGE.

VNN1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811329 Vanin-1 Antibody WB, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Malaria

  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria
Cystinosis

  • Cystine Storage Disease

  • Cystine Diathesis

  • Cystine Disease

  • Cystinoses

  • Protein Defect Of Cystin Transport

  • Cystin Transport, Protein Defect Of

  • Nephropathic Cystinosis

  • Protein Defect Of Cystine Transport
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168981 Larubrilstat Inhibitor 98.89% Unkown
HY-RS15666 VNN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18797 Vnn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25286 Vnn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus VNN1 MGD MGI:108395
Macaca mulatta VNN1 VGNC VGNC:83967
Bos taurus VNN1 VGNC VGNC:36807
Rattus norvegicus VNN1 RGD RGD:1310075
Others VNN1 NCBI