2. Gene
  3. CPNE1 - copine 1 Gene

CPNE1 - copine 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CPN1; COPN1

Gene ID: 8904 | Gene type: protein coding

About CPNE1

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,626,044-35,664,900 (from NCBI)

This gene has 28 transcripts (splice variants), 177 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 33.6), placenta (RPKM 33.3) and 25 other tissues.

Summary

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an Integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Aug 2008]

CPNE1 Products(6)

mRNA Protein Name
NM_001198863.2 NP_001185792.1 copine-1 isoform c
NM_003915.6 NP_003906.2 copine-1 isoform b
NM_152925.3 NP_690902.1 copine-1 isoform a
NM_152926.3 NP_690903.1 copine-1 isoform a
NM_152927.3 NP_690904.1 copine-1 isoform a
NM_152928.3 NP_690905.1 copine-1 isoform a

CPNE1 Protein Structure

C2

C2: C2 domain (12 - 97)

C2

C2: C2 domain (144 - 227)

Copine

Copine: Copine (304 - 451)

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  • 537 a.a.
Protein Preferred Names Protein Names

copine-1

chromobindin 17

Recombinant CPNE1 Proteins

Cat. No. Product Name Accession Purity
HY-P70097 Copine-1/CPNE1 Protein, Human (His) Q99829 (M1-A537) ≥95%

Related Diseases

Diseases Alias
Schizophrenia 19

SCZD19

Schizophrenia 19 With Or Without An Affective Disorder

Schizophrenia 19, Susceptibility To

{Schizophrenia 19, Susceptibility To}
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03103 CPNE1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CPNE1 VGNC VGNC:99050
Mus musculus CPNE1 MGD MGI:2386621
Rattus norvegicus CPNE1 RGD RGD:1311148
Canis familiaris CPNE1 VGNC VGNC:39560
Bos taurus CPNE1 VGNC VGNC:27658
Others CPNE1 NCBI