H2BC11 - H2B clustered histone 11 Gene

Also Known as H2BJ; H2B/r; H2BFR; HIST1H2BJ

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8970

About H2BC11

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:27,132,316-27,132,795 (from NCBI)

This gene has 3 transcripts (splice variants), 126 orthologues and 21 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

H2BC11 Products (1)

mRNA	Protein	Name
NM_021058.4	NP_066402.2	histone H2B type 1-J

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	11859126	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20498094	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	12860195	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	11859126	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	11859126	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	11859126	GOA
involved in innate immune response in mucosa	IDA IDA: Inferred from direct assay	12860195	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	11859126	GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	11859126	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CENP-A containing nucleosome	IPI IPI: Inferred from physical interaction	21743476	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	11859126	GOA
part of nucleosome	IPI IPI: Inferred from physical interaction	20498094	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16319397	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	11859126	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H2BC11 Protein Structure

Histone

0
100
126 a.a.

Protein Preferred Names	Protein Names
histone H2B type 1-J	H2B histone family, member R

Recombinant H2BC11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72329	H2BC11 Protein, Human	P06899 (P2-K126)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Arteriovenous Malformations Of The Brain	Cerebral Arteriovenous Malformation Intracranial Arteriovenous Malformation Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To Intracranial Arteriovenous Malformations Bavm Cerebral Arteriovenous Malformations Intracranial Hemorrhage In Brain Cerebrovascular Malformations Arteriovenous Malformation Of The Brain, Somatic Intracranial Avm Arteriovenous Malformations Cerebral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05959	H2BC11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	H2BC11	RGD	RGD:1562346
Mus musculus	H2BC11	MGD	MGI:2448415