Angpt2 - angiopoietin 2 Gene

Also Known as Agpt2; Ang-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 89805

Summary

Predicted to enable receptor tyrosine kinase binding activity. Involved in several processes, including blood vessel development; maternal process involved in female pregnancy; and positive regulation of angiogenesis. Located in several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study several diseases, including ischemia (multiple); membranoproliferative glomerulonephritis; portal hypertension; retinal disease (multiple); and uremia. Biomarker of several diseases, including Caroli disease; artery disease (multiple); glomerulonephritis (multiple); musculoskeletal system Cancer (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human ANGPT2 (angiopoietin 2). [provided by Alliance of Genome Resources, Apr 2022]

Angpt2 Products (1)

mRNA Protein Name
NM_134454.1 NP_604449.1 angiopoietin-2 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IEP
IEP: Inferred from expression pattern
16439712 RGD
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
16437624 RGD
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
16176970 RGD
involved in germ cell development IEP
IEP: Inferred from expression pattern
18996974 RGD
involved in glomerulus vasculature development IMP
IMP: Inferred from mutant phenotype
20056745 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
16452728 RGD
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
15542434 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
18342145 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
15048134 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
17943991 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19012730 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19672036 RGD
Cellular Component GO Annotation Evidence References Source
located in cell projection IDA
IDA: Inferred from direct assay
18272601 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
16628643 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

angiopoietin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00688 ANGPT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117733 Zerumin A Inhibitor / Unkown
HY-RS16719 Angpt2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23155 Angpt2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Angpt2 NCBI NCBI:285