ANGPT2 - angiopoietin 2 Gene
Also Known as ANG2; AGPT2; LMPHM10
Species: Homo sapiens
About ANGPT2
This gene has 4 transcripts (splice variants), 199 orthologues, 25 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 6.2), urinary bladder (RPKM 5.1) and 19 other tissues.
Summary
This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell Apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020]
ANGPT2 Products (6)
| mRNA | Protein | Name |
|---|---|---|
| NM_001118887.2 | NP_001112359.1 | angiopoietin-2 isoform b precursor |
| NM_001118888.2 | NP_001112360.1 | angiopoietin-2 isoform c precursor |
| NM_001147.3 | NP_001138.1 | angiopoietin-2 isoform a precursor |
| NM_001386335.1 | NP_001373264.1 | angiopoietin-2 isoform d precursor |
| NM_001386336.1 | NP_001373265.1 | angiopoietin-2 isoform e precursor |
| NM_001386337.1 | NP_001373266.1 | angiopoietin-2 isoform f precursor |
ANGPT2 Protein Structure
Fibrinogen_C: Fibrinogen beta and gamma chains, C-terminal globular domain (281 - 493)
- 0
- 100
- 200
- 300
- 400
- 496 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
angiopoietin-2 |
|
ANGPT2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
ANGPT2 | O15123 | TEK | Homo sapiens | Q02763 | 20708158 | |
|
Intra
|
ANGPT2 | O15123 | TEK | Homo sapiens | Q02763 | 20708158 | |
|
Intra
|
ANGPT2 | O15123 | TEK | Homo sapiens | Q02763 | 20708158 |
Recombinant ANGPT2 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7510 | Angiopoietin-2 Protein, Human (HEK293, His) | O15123-1 (K275-F496) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72827 | Angiopoietin-2 Protein, Human (HEK293, Fc) | O15123-1 (Y19-F496) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72828 | Angiopoietin-2 Protein, Human (CHO, His) | O15123-1 (Y19-F496) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72829 | Angiopoietin-2 Protein, Human (478a.a, HEK293, His) | O15123-1 (Y19-F496) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P78061 | Angiopoietin-2 Protein, Human (Biotinylated, HEK293, His-Avi) | O15123-1 (K275-F496) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78381 | Angiopoietin-2 Protein, Human (HEK293, His-Avi) | O15123-1 (K275-F496) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78651 | FITC-Labeled Angiopoietin-2 Protein, Human (HEK293, His-Avi) | O15123-1 (K275-F496) | ≥ 90%, as determined by reducing SDS-PAGE. |
ANGPT2 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81853 | Angiopoietin 2 Antibody (YA1598) | WB, IHC-P | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Lymphatic Malformation 10 |
|
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| Hydrops Fetalis, Nonimmune |
|
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| Placental Insufficiency |
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| Microcephaly 1, Primary, Autosomal Recessive |
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| Primary Lymphedema |
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| Microvascular Complications Of Diabetes 1 |
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| Pyogenic Granuloma |
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| Macular Holes |
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| Primary Autosomal Recessive Microcephaly |
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| Preretinal Fibrosis |
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| Angiosarcoma |
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| Intermittent Claudication |
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| Hemangioma |
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| Cellulitis |
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| Retinal Vein Occlusion |
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| Microvascular Complications Of Diabetes 5 |
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| Placenta Accreta |
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| Psoriatic Arthritis |
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| Macrophage Activation Syndrome |
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| Malaria |
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| Pulmonary Embolism |
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| Diabetic Macular Edema |
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| Congestive Heart Failure |
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| Poems Syndrome |
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| Kuhnt-Junius Degeneration |
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| Capillary Disease |
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| Angiodysplasia |
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| Glioblastoma |
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| Endometrial Cancer |
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| Lung Cancer |
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| Exudative Vitreoretinopathy 1 |
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| Background Diabetic Retinopathy |
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| Macular Retinal Edema |
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| Laryngeal Squamous Cell Carcinoma |
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| Retinal Vascular Occlusion |
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| Colorectal Cancer |
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| Hepatocellular Carcinoma |
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| Gastric Cancer |
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| Malignant Renovascular Hypertension |
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| Retinal Vascular Disease |
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| Arteriovenous Malformation |
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| Macular Degeneration, Age-Related, 1 |
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| Diabetes Mellitus |
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| Thrombocytopenia |
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| Familiar Ovarian Carcinoma |
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| Ovarian Cancer |
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| Myocardial Infarction |
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| Breast Cancer |
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| Prostate Cancer |
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| Inflammatory Bowel Disease |
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| Malignant Secondary Hypertension |
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| Respiratory Failure |
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| Lipoprotein Quantitative Trait Locus |
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| Eye Disease |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | ANGPT2 | VGNC | VGNC:37855 |
| Macaca mulatta | ANGPT2 | VGNC | VGNC:69811 |
| Mus musculus | ANGPT2 | MGD | MGI:1202890 |
| Rattus norvegicus | ANGPT2 | RGD | RGD:621861 |
| Bos taurus | ANGPT2 | VGNC | VGNC:25888 |
| Felis catus | ANGPT2 | VGNC | VGNC:67546 |
| Others | ANGPT2 | NCBI |