2. Gene
  3. CDKL2 - cyclin dependent kinase like 2 Gene

CDKL2 - cyclin dependent kinase like 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P56; KKIAMRE

Gene ID: 8999 | Gene type: protein coding

About CDKL2

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,576,496-75,630,528 (from NCBI)

This gene has 4 transcripts (splice variants), 149 orthologues and 26 paralogues. Biased expression in testis (RPKM 7.0), brain (RPKM 3.3) and 6 other tissues.

Summary

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]

CDKL2 Products(2)

mRNA Protein Name
NM_001330724.2 NP_001317653.1 cyclin-dependent kinase-like 2 isoform 2
NM_003948.5 NP_003939.1 cyclin-dependent kinase-like 2 isoform 1

CDKL2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (4 - 287)

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  • 493 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase-like 2

CDC2-related kinase

Recombinant CDKL2 Proteins

Cat. No. Product Name Accession Purity
HY-P76247 CDKL2 Protein, Human (sf9, His) Q92772 (M1-H493) ≥95%

Related Diseases

Diseases Alias
Meckel Syndrome, Type 4

Meckel Syndrome 4

MKS4

Meckel-Gruber Syndrome, Type 4

Meckel Syndrome Type 4
Orofaciodigital Syndrome Vi

OFD6

Varadi-Papp Syndrome

Varadi Syndrome

Joubert Syndrome With Orofaciodigital Defect

Orofaciodigital Syndrome Type 6

Orofaciodigital Syndrome 6

Oral-Facial-Digital Syndrome, Type Vi

Ofds Vi

Polydactyly, Cleft Lip/Palate Or Lingual Lump, And Psychomotor Retardation

Polydactyly Cleft Lip Palate Psychomotor Retardation

Oral-Facial-Digital Syndrome Type 6

Polydactyly-Cleft Lip/Palate-Psychomotor Retardation Syndrome

Polydactyly - Cleft Lip/Palate - Psychomotor Retardation

Váradi Syndrome

Váradi-Papp Syndrome

Joubert Syndrome With Oral-Facial-Digital Syndrome

Oral-Facial-Digital Syndrome 6

Joubert-Orofaciodigital Syndrome

Orofaciodigital Syndrome, Type Vi
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02406 CDKL2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CDKL2 VGNC VGNC:27139
Macaca mulatta CDKL2 VGNC VGNC:70987
Mus musculus CDKL2 MGD MGI:1858227
Felis catus CDKL2 VGNC VGNC:60709
Rattus norvegicus CDKL2 RGD RGD:1309625
Canis familiaris CDKL2 VGNC VGNC:39065
Others CDKL2 NCBI