CDKL2 - cyclin dependent kinase like 2 Gene

Also Known as P56; KKIAMRE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8999

About CDKL2

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,576,496-75,630,528 (from NCBI)

This gene has 4 transcripts (splice variants), 149 orthologues and 26 paralogues. Biased expression in testis (RPKM 7.0), brain (RPKM 3.3) and 6 other tissues.

Summary

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]

CDKL2 Products (2)

mRNA Protein Name
NM_001330724.2 NP_001317653.1 cyclin-dependent kinase-like 2 isoform 2
NM_003948.5 NP_003939.1 cyclin-dependent kinase-like 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDKL2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (4 - 287)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase-like 2

  • CDC2-related kinase

CDKL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
CDKL2 Q92772 HSP90AA5P Homo sapiens Q58FG0
Anti Tag CoIP
28514442
Intra
CDKL2 Q92772 HSP90AA5P Homo sapiens Q58FG0
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDKL2 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P76247 CDKL2 Protein, Human (sf9, His) Q92772 (M1-H493) ≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Meckel Syndrome, Type 4

  • Meckel Syndrome 4

  • MKS4

  • Meckel-Gruber Syndrome, Type 4

  • Meckel Syndrome Type 4
Orofaciodigital Syndrome Vi

  • OFD6

  • Varadi-Papp Syndrome

  • Varadi Syndrome

  • Joubert Syndrome With Orofaciodigital Defect

  • Orofaciodigital Syndrome Type 6

  • Orofaciodigital Syndrome 6

  • Oral-Facial-Digital Syndrome, Type Vi

  • Ofds Vi

  • Polydactyly, Cleft Lip/Palate Or Lingual Lump, And Psychomotor Retardation

  • Polydactyly Cleft Lip Palate Psychomotor Retardation

  • Oral-Facial-Digital Syndrome Type 6

  • Polydactyly-Cleft Lip/Palate-Psychomotor Retardation Syndrome

  • Polydactyly - Cleft Lip/Palate - Psychomotor Retardation

  • Váradi Syndrome

  • Váradi-Papp Syndrome

  • Joubert Syndrome With Oral-Facial-Digital Syndrome

  • Oral-Facial-Digital Syndrome 6

  • Joubert-Orofaciodigital Syndrome

  • Orofaciodigital Syndrome, Type Vi
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-162653 SGC-CDKL2/AAK1/BMP2K-1 98.55% Unkown
HY-RS02406 CDKL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19416 Cdkl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CDKL2 VGNC VGNC:27139
Macaca mulatta CDKL2 VGNC VGNC:70987
Mus musculus CDKL2 MGD MGI:1858227
Felis catus CDKL2 VGNC VGNC:60709
Rattus norvegicus CDKL2 RGD RGD:1309625
Canis familiaris CDKL2 VGNC VGNC:39065
Others CDKL2 NCBI