CDKL2 Protein, Human (sf9, His)
Cyclin-dependent kinase-like 2 (CDKL2), is a member of the CDC2-related serine/threonine protein kinase family. CDKL2 is tightly associated with tumor progression and is a regulator of epithelial-mesenchymal transition (EMT). CDKL2 also plays a role in cognitive functions, emotion, and neurological disorders. CDKL2 Protein, Human (sf9, His) is the recombinant human-derived CDKL2 protein, expressed by Sf9 insect cells , with N-His labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Cyclin-dependent kinase-like 2 (CDKL2), is a member of the CDC2-related serine/threonine protein kinase family. CDKL2 is tightly associated with tumor progression and is a regulator of epithelial-mesenchymal transition (EMT). CDKL2 also plays a role in cognitive functions, emotion, and neurological disorders[1][2]. CDKL2 Protein, Human (sf9, His) is the recombinant human-derived CDKL2 protein, expressed by Sf9 insect cells , with N-His labeled tag.
Cyclin-dependent kinase-like 2 (CDKL2), also known as P56 and KKIAMRE, is a member of the CDC2-related serine/threonine protein kinase family. CDKL2 is tightly associated with tumor progression, such as prostate cancer, breast cancer, hepatocellular carcinoma (HCC), glioma, and gastric cancer[1]. In addition, CDKL2 is a regulator of epithelial-mesenchymal transition (EMT) and can enhance mesenchymal traits and stem-cell like phenotypes of breast cancer cells[2]. CDKL2 also plays a role in cognitive functions, emotion, and neurological disorders[1].
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-His
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Accession
Q92772 (M1-H493)
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Molecular Construction
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N-term
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His
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CDKL2 (M1-H493)
Accession # Q92772 -
C-term
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Protein Length
Full Length
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Synonyms
CDKL2; Serine/Threonine Protein Kinase KKIAMRE; Cyclin Dependent Kinase Like 2; Serine/Threonine-Protein Kinase KKIAMRE; Cyclin-Dependent Kinase-Like 2; Testicular Tissue Protein Li 35; KKIAMRE; P56 KKIAMRE Protein Kinase; P56; Cyclin-Dependent Kinase; Pr
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AA Sequence
MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQLKVQKDARNVSLSKKSQNRKKEKEKDDSLVEERKTLVVQDTNADPKIKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTHNLSAVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNINVTTLVSGPPLSDDSGADLPQMEHQH
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Predicted Molecular Mass
58.3 kDa
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Molecular Weight
Approximately 63 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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