NAT1 - N-acetyltransferase 1 Gene

Also Known as AAC1; MNAT; NATI; NAT-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9

About NAT1

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:18,170,467-18,223,689 (from NCBI)

This gene has 8 transcripts (splice variants), 310 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 3.6), duodenum (RPKM 2.9) and 23 other tissues.

Summary

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and Other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

NAT1 Products (10)

mRNA	Protein	Name
NM_000662.8	NP_000653.3	arylamine N-acetyltransferase 1 isoform a
NM_001160170.4	NP_001153642.1	arylamine N-acetyltransferase 1 isoform a
NM_001160171.4	NP_001153643.1	arylamine N-acetyltransferase 1 isoform a
NM_001160172.4	NP_001153644.1	arylamine N-acetyltransferase 1 isoform a
NM_001160173.4	NP_001153645.1	arylamine N-acetyltransferase 1 isoform a
NM_001160174.3	NP_001153646.1	arylamine N-acetyltransferase 1 isoform a
NM_001160175.4	NP_001153647.1	arylamine N-acetyltransferase 1 isoform b
NM_001160176.4	NP_001153648.1	arylamine N-acetyltransferase 1 isoform b
NM_001160179.3	NP_001153651.1	arylamine N-acetyltransferase 1 isoform a
NM_001291962.2	NP_001278891.1	arylamine N-acetyltransferase 1 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAT1 Protein Structure

Acetyltransf_2

0
100
200
290 a.a.

Protein Preferred Names	Protein Names
arylamine N-acetyltransferase 1	N-acetyltransferase 1 (arylamine N-acetyltransferase)

NAT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NAT1	P18440	ICAM1	Homo sapiens	P05362	Anti Tag CoIP	33961781
Intra	NAT1	P18440	ICAM1	Homo sapiens	P05362	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

NAT1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83543	NAT1 Antibody (YA3288)	WB	Human, Mouse, Rat
HY-P83543A	NAT1 Antibody (YA3288)(PBS only)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Papillary Transitional Carcinoma	Papillary Transitional Cell Carcinoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Clubfoot	Congenital Talipes Equinovarus Congenital Clubfoot Congenital Equinovarus Equinovarus Deformity Of Foot Club Foot
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-161875	NAT1-IN-1	Inhibitor	99.77%	Unkown
HY-RS04282	EIF4G2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09039	NAT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13221	SLC38A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13224	SLC38A6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13306	SLC6A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18486	Nat1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22043	Slc38a3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24968	Nat1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28560	Slc38a3 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NAT1	RGD	RGD:70490
Macaca mulatta	NAT1	VGNC	VGNC:75133