CCRL2 - C-C motif chemokine receptor like 2 Gene

Also Known as HCR; CKRX; CRAM; ACKR5; CRAM-A; CRAM-B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9034

About CCRL2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:46,407,259-46,409,523 (from NCBI)

This gene has 7 transcripts (splice variants), 144 orthologues and 23 paralogues. Broad expression in appendix (RPKM 6.4), lung (RPKM 6.3) and 20 other tissues.

Summary

This gene encodes a Chemokine Receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the Chemokine Receptor gene cluster is located. [provided by RefSeq, Jul 2008]

CCRL2 Products (2)

mRNA Protein Name
NM_001130910.2 NP_001124382.1 C-C chemokine receptor-like 2 isoform 2
NM_003965.5 NP_003956.2 C-C chemokine receptor-like 2 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables CCR chemokine receptor binding IPI
IPI: Inferred from physical interaction
20002784 GOA
enables chemokine receptor binding IPI
IPI: Inferred from physical interaction
14530373 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
20002784 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCRL2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (56 - 300)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
Protein Preferred Names Protein Names

C-C chemokine receptor-like 2

  • atypical chemokine receptor 5

CCRL2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810954 CCRL2 Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Inflammatory Bowel Disease 18

  • IBD18
Autoimmune Disease Of Skin And Connective Tissue
Chronic Mucocutaneous Candidiasis

  • Candidiasis, Chronic Mucocutaneous

  • Cmc

  • Candidiasis Chronic Mucocutaneous
Nail Disease

  • Nail Diseases

  • Abnormality Of The Nail

  • Nail Anomaly
Crohn'S Disease

  • Crohn Disease

  • Pediatric Crohn'S Disease

  • Regional Enteritis

  • Crohn'S Disease Of Large Bowel

  • Granulomatous Colitis

  • Enteritis, Granulomatous

  • Enteritis

  • Crohn'S Disease Of Colon

  • Colitis, Granulomatous

  • Crohn'S Enteritis

  • Enteritis, Regional

  • Ileitis

  • Adenoviral Enteritis

  • Acute Gastroenteropathy Due To Norwalk Agent

  • Viral Gastroenteritis Due To Norwalk Agent

  • Winter Vomiting

  • Epidemic Winter Vomiting Disease

  • Small Round Structured Virus Enteritis

  • Epidemic Vomiting Syndrome

  • Epidemic Vomiting

  • Epidemic Nausea

  • Epidemic Viral Gastroenteritis Due To Norwalk Virus

  • Noroviral Enteritis

  • Crohn Disease Nos

  • Crohns

  • Cd - [Crohn'S Disease]

  • Regional Enteritis Of Bowel

  • Crohn'S Regional Enteritis

  • Cobble-Stone Appearance Of Intestine

  • Intestinal Ulcer And Erosion Due To Crohn Disease

  • Granulomatous Enteritis
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Behcet Syndrome

  • Behcet Disease

  • Behcet'S Syndrome

  • Behcet'S Disease

  • Behçet Disease

  • Bd

  • Adamantiades-Behcet Disease

  • Triple Symptom Complex

  • Behçet'S Disease

  • Behet'S Syndrome

  • Bd Syndrome

  • Behçet Syndrome

  • Behçet'S Syndrome

  • Behcet Triple Symptom Complex

  • Malignant Aphthosis

  • Old Silk Route Disease

  • Adamantiades-Behçet Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02175 CCRL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174739 Human CCRL2 mRNA / Unkown
HY-RS18989 Ccrl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25478 Ccrl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CCRL2 VGNC VGNC:38918
Rattus norvegicus CCRL2 RGD RGD:1311811
Macaca mulatta CCRL2 VGNC VGNC:70743
Bos taurus CCRL2 VGNC VGNC:26990
Mus musculus CCRL2 MGD MGI:1920904
Others CCRL2 NCBI