CCRL2 - C-C motif chemokine receptor like 2 Gene

Homo sapiens

Also known as HCR; CKRX; CRAM; ACKR5; CRAM-A; CRAM-B

Gene ID: 9034 | Gene type: protein coding

About CCRL2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:46,407,259-46,409,523 (from NCBI)

This gene has 7 transcripts (splice variants), 144 orthologues and 23 paralogues. Broad expression in appendix (RPKM 6.4), lung (RPKM 6.3) and 20 other tissues.

Summary

This gene encodes a Chemokine Receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the Chemokine Receptor gene cluster is located. [provided by RefSeq, Jul 2008]

CCRL2 Products(2)

mRNA	Protein	Name
NM_001130910.2	NP_001124382.1	C-C chemokine receptor-like 2 isoform 2
NM_003965.5	NP_003956.2	C-C chemokine receptor-like 2 isoform 1

CCRL2 Protein Structure

7tm_1

0
100
200
300
344 a.a.

Protein Preferred Names

Protein Names

C-C chemokine receptor-like 2

atypical chemokine receptor 5

Related Diseases

Diseases

Alias

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Inflammatory Bowel Disease 18

IBD18

Autoimmune Disease Of Skin And Connective Tissue

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02175	CCRL2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CCRL2	VGNC	VGNC:38918
Rattus norvegicus	CCRL2	RGD	RGD:1311811
Macaca mulatta	CCRL2	VGNC	VGNC:70743
Bos taurus	CCRL2	VGNC	VGNC:26990
Mus musculus	CCRL2	MGD	MGI:1920904

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