GPRC5A - G protein-coupled receptor class C group 5 member A Gene

Also Known as RAI3; TIG1; RAIG1; GPCR5A; PEIG-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9052

About GPRC5A

Cytogenetic location: 12p13.1 Genomic coordinates (GRCh38): 12:12,891,562-12,917,937 (from NCBI)

This gene has 6 transcripts (splice variants), 195 orthologues and 3 paralogues. Biased expression in lung (RPKM 125.2), colon (RPKM 33.4) and 9 other tissues.

Summary

This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]

GPRC5A Products (1)

mRNA Protein Name
NM_003979.4 NP_003970.1 retinoic acid-induced protein 3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25311788 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
18000218 GOA
located in vesicle IDA
IDA: Inferred from direct assay
25468996 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPRC5A Protein Structure

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (38 - 268)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
Protein Preferred Names Protein Names

retinoic acid-induced protein 3

  • G-protein coupled receptor family C group 5 member A

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117295A 7-Fluorotryptamine hydrochloride 98.87% Unkown
HY-RS05749 GPRC5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20163 Gprc5a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26667 Gprc5a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GPRC5A VGNC VGNC:73159
Rattus norvegicus GPRC5A RGD RGD:1310804
Canis familiaris GPRC5A VGNC VGNC:41450
Bos taurus GPRC5A VGNC VGNC:29606
Mus musculus GPRC5A MGD MGI:1891250
Felis catus GPRC5A VGNC VGNC:69226
Others GPRC5A NCBI