2. GPCR/G Protein
  3. Arrestin
  4. 7-Fluorotryptamine hydrochloride

7-Fluorotryptamine hydrochloride 

Cat. No.: HY-117295A Purity: 98.82%
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7-Fluorotryptamine hydrochloride is a potent agonist of GPRC5A. 7-Fluorotryptamine hydrochloride induces GPRC5A-mediated β-arrestin recruitment. 7-Fluorotryptamine hydrochloride can be used for research of immune and cancer signaling.

For research use only. We do not sell to patients.

7-Fluorotryptamine hydrochloride Chemical Structure

7-Fluorotryptamine hydrochloride Chemical Structure

CAS No. : 159730-09-3

Size Price Stock Quantity
1 mg USD 30 In-stock
5 mg USD 81 In-stock
10 mg USD 130 In-stock
25 mg USD 270 In-stock
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Based on 1 publication(s) in Google Scholar

7-Fluorotryptamine hydrochloride Related Antibodies

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Description

7-Fluorotryptamine hydrochloride is a potent agonist of GPRC5A. 7-Fluorotryptamine hydrochloride induces GPRC5A-mediated β-arrestin recruitment. 7-Fluorotryptamine hydrochloride can be used for research of immune and cancer signaling[1].

IC50 & Target

GPRC5A[1]
In Vitro

7-Fluorotryptamine (100 μM) hydrochloride induces β-arrestin recruitment by GPRC5A in the PRESTO-Tango assay[1].
7-Fluorotryptamine (50 μM, 8 h) hydrochloride together with TNFα down-regulates some TNFα-induced genes (eg: IL41A, CXCL10, CSF2) in WT and GPRC5A-KO cells[1].
7-Fluorotryptamine (0-100 μM, 16 h) hydrochloride exhibits no toxicity for mammalian cells (HTLA, HT-29 cell)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

7-Fluorotryptamine hydrochloride Related Antibodies
Molecular Weight

214.67

Formula

C10H12ClFN2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NCCC1=CNC2=C(C=CC=C21)F.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (582.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6583 mL 23.2916 mL 46.5831 mL
5 mM 0.9317 mL 4.6583 mL 9.3166 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6583 mL 23.2916 mL 46.5831 mL 116.4578 mL
5 mM 0.9317 mL 4.6583 mL 9.3166 mL 23.2916 mL
10 mM 0.4658 mL 2.3292 mL 4.6583 mL 11.6458 mL
15 mM 0.3106 mL 1.5528 mL 3.1055 mL 7.7639 mL
20 mM 0.2329 mL 1.1646 mL 2.3292 mL 5.8229 mL
25 mM 0.1863 mL 0.9317 mL 1.8633 mL 4.6583 mL
30 mM 0.1553 mL 0.7764 mL 1.5528 mL 3.8819 mL
40 mM 0.1165 mL 0.5823 mL 1.1646 mL 2.9114 mL
50 mM 0.0932 mL 0.4658 mL 0.9317 mL 2.3292 mL
60 mM 0.0776 mL 0.3882 mL 0.7764 mL 1.9410 mL
80 mM 0.0582 mL 0.2911 mL 0.5823 mL 1.4557 mL
100 mM 0.0466 mL 0.2329 mL 0.4658 mL 1.1646 mL
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7-Fluorotryptamine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Fluorotryptamine159730-09-3ArrestinGPRC5Aimmunecancerβ-arrestinHTLAHT-29Inhibitorinhibitorinhibit

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