BOD1 - biorientation of chromosomes in cell division 1 Gene

Also Known as FAM44B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 91272

About BOD1

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:173,607,145-173,616,650 (from NCBI)

This gene has 7 transcripts (splice variants), 124 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 15.5), ovary (RPKM 14.9) and 25 other tissues.

Summary

Enables protein Phosphatase 2A binding activity and protein Phosphatase Inhibitor activity. Involved in mitotic sister chromatid segregation; negative regulation of phosphoprotein Phosphatase activity; and protein localization to chromosome, centromeric region. Located in centrosome; spindle microtubule; and spindle pole. Part of outer kinetochore. [provided by Alliance of Genome Resources, Apr 2022]

BOD1 Products (2)

mRNA	Protein	Name
NM_001159651.3	NP_001153123.1	biorientation of chromosomes in cell division protein 1 isoform b
NM_138369.3	NP_612378.1	biorientation of chromosomes in cell division protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein phosphatase 2A binding	IPI IPI: Inferred from physical interaction	24157919	GOA
enables protein phosphatase inhibitor activity	IDA IDA: Inferred from direct assay	24157919	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	17938248	GOA
involved in mitotic sister chromatid biorientation	IMP IMP: Inferred from mutant phenotype	17938248	GOA
involved in mitotic sister chromatid cohesion, centromeric	IMP IMP: Inferred from mutant phenotype	24157919	GOA
involved in protein localization to chromosome, centromeric region	IMP IMP: Inferred from mutant phenotype	17938248	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Set1C/COMPASS complex	IPI IPI: Inferred from physical interaction	23508102	GOA
located in centrosome	IDA IDA: Inferred from direct assay	17938248	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	17938248	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	17938248	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	17938248	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BOD1 Protein Structure

COMPASS-Shg1

0
100
185 a.a.

Protein Preferred Names	Protein Names
biorientation of chromosomes in cell division protein 1	biorientation defective 1

BOD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BOD1	Q96IK1	WDTC1	Homo sapiens	Q8N5D0	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Miliaria Rubra	Miliaria Prickly Heat Miliaria Crystallina

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01568	BOD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01569	BOD1L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BOD1	RGD	RGD:1305622
Mus musculus	BOD1	MGD	MGI:1916806
Macaca mulatta	BOD1	VGNC	VGNC:84284
Others	BOD1	NCBI