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UBE2L6 - ubiquitin conjugating enzyme E2 L6 Gene

Also Known as RIG-B; UBCH8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9246

About UBE2L6

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,551,662-57,567,935 (from NCBI)

This gene has 5 transcripts (splice variants), 136 orthologues and 12 paralogues. Ubiquitous expression in spleen (RPKM 48.8), lymph node (RPKM 38.4) and 24 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes (E1s), ubiquitin-conjugating Enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

UBE2L6 Products (2)

mRNA	Protein	Name
NM_004223.5	NP_004214.1	ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 1
NM_198183.3	NP_937826.1	ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables ISG15 transferase activity	IDA IDA: Inferred from direct assay	15131269	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10085091	GOA
enables ubiquitin binding	EXP EXP: Inferred from Experiment	15485925	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ISG15-protein conjugation	IDA IDA: Inferred from direct assay	15131269	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	28724761	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2L6 Protein Structure

UQ_con

0
100
153 a.a.

Protein Preferred Names	Protein Names
ubiquitin/ISG15-conjugating enzyme E2 L6	E2 ubiquitin-conjugating enzyme L6

UBE2L6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBE2L6	O14933	RNF144B	Homo sapiens	Q7Z419	Anti Tag CoIP	16427630
Intra	UBE2L6	O14933	DTX3	Homo sapiens	Q8N9I9	Y2H Prey Pooling	32296183
Intra	UBE2L6	O14933	DTX3	Homo sapiens	Q8N9I9	Validated Y2H	32296183
Intra	UBE2L6	O14933	DTX3	Homo sapiens	Q8N9I9	Y2H Array	32296183
Intra	UBE2L6	O14933	MID1	Homo sapiens	O15344	Y2H Array	32296183
Intra	UBE2L6	O14933	MID1	Homo sapiens	O15344	Validated Y2H	32296183
Intra	UBE2L6	O14933	MID1	Homo sapiens	O15344	Y2H Prey Pooling	32296183
Intra	UBE2L6	O14933	TRIM8	Homo sapiens	Q9BZR9	Y2H Array	19549727
Intra	UBE2L6	O14933	TRIM8	Homo sapiens	Q9BZR9	Y2H Prey Pooling	32296183
Intra	UBE2L6	O14933	TRIM8	Homo sapiens	Q9BZR9	Validated Y2H	32296183
Intra	UBE2L6	O14933	TRIM8	Homo sapiens	Q9BZR9	Y2H Array	32296183
Intra	UBE2L6	O14933	RBCK1	Homo sapiens	Q9BYM8	Y2H Prey Pooling	25416956
Intra	UBE2L6	O14933	RBCK1	Homo sapiens	Q9BYM8	Y2H Prey Pooling	32296183
Intra	UBE2L6	O14933	RBCK1	Homo sapiens	Q9BYM8	Validated Y2H	32296183
Intra	UBE2L6	O14933	RBCK1	Homo sapiens	Q9BYM8	Y2H Array	32296183
Intra	UBE2L6	O14933	LONRF1	Homo sapiens	Q17RB8	Y2H Prey Pooling	32296183
Intra	UBE2L6	O14933	LONRF1	Homo sapiens	Q17RB8	Y2H Array	32296183
Intra	UBE2L6	O14933	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	32296183
Intra	UBE2L6	O14933	RNF19B	Homo sapiens	Q6ZMZ0	Anti Bait CoIP	16709802
Intra	UBE2L6	O14933	TRIM62	Homo sapiens	Q9BVG3	Y2H Array	32296183
Intra	UBE2L6	O14933	TRIM62	Homo sapiens	Q9BVG3	Y2H Prey Pooling	32296183
Intra	UBE2L6	O14933	TRIM62	Homo sapiens	Q9BVG3	Validated Y2H	32296183
Intra	UBE2L6	O14933	ARIH2	Homo sapiens	O95376	Y2H Array	19549727
Intra	UBE2L6	O14933	ARIH2	Homo sapiens	O95376	Validated Y2H	25416956
Intra	UBE2L6	O14933	ARIH2	Homo sapiens	O95376	Anti Tag CoIP	33961781
Intra	UBE2L6	O14933	ARIH2	Homo sapiens	O95376	Y2H Prey Pooling	32296183
Intra	UBE2L6	O14933	ARIH2	Homo sapiens	O95376	Y2H	19549727
Intra	UBE2L6	O14933	ARIH2	Homo sapiens	O95376	Validated Y2H	32296183
Intra	UBE2L6	O14933	ARIH2	Homo sapiens	O95376	Y2H Array	32296183
Intra	UBE2L6	O14933	ARIH2	Homo sapiens	O95376	Y2H Array	31515488
Intra	UBE2L6	O14933	RNF216	Homo sapiens	Q9NWF9	Validated Y2H	32296183
Intra	UBE2L6	O14933	RNF216	Homo sapiens	Q9NWF9	Y2H Array	32296183
Intra	UBE2L6	O14933	RNF216	Homo sapiens	Q9NWF9	Y2H Prey Pooling	32296183
Intra	UBE2L6	O14933	LITAF	Homo sapiens	Q99732	Validated Y2H	32814053
Intra	UBE2L6	O14933	LITAF	Homo sapiens	Q99732	Y2H Array	32814053
Intra	UBE2L6	O14933	LITAF	Homo sapiens	Q99732	Y2H Pooling	32814053
Cross	UBE2L6	O14933	Rnf40	Rattus norvegicus	Q8CJB9	Anti Tag CoIP	12121982

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2L6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71020	UBE2L6 Protein, Human (His)	O14933 (M1-S153)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Immunodeficiency 38 With Basal Ganglia Calcification	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Isg15 Deficiency IMD38 Immunodeficiency 38, Mycobacteriosis, Autosomal Recessive Immunodeficiency 38 Isg15 Deficiency, Autosomal Recessive Immunodeficiency 38, With Basal Ganglia Calcification Autosomal Recessive Isg15 Deficiency Msmd Due To Complete Isg15 Deficiency Immunodeficiency, Type 38

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15354	UBE2L6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21971	Ube2l6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28488	Ube2l6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UBE2L6	VGNC	VGNC:36588
Rattus norvegicus	UBE2L6	RGD	RGD:1307960
Canis familiaris	UBE2L6	VGNC	VGNC:48058
Mus musculus	UBE2L6	MGD	MGI:1914500
Macaca mulatta	UBE2L6	VGNC	VGNC:78698
Felis catus	UBE2L6	VGNC	VGNC:66761
Others	UBE2L6	NCBI