Rnf40 - ring finger protein 40 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 266712

Summary

Enables syntaxin-1 binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-protein transferase activity. Involved in positive regulation of cellular protein metabolic process; response to peptide hormone; and ubiquitin-dependent protein catabolic process. Located in axon terminus and cytosol. Is extrinsic component of membrane. Part of protein-containing complex. Biomarker of nephrogenic diabetes insipidus. Orthologous to human RNF40 (ring finger protein 40). [provided by Alliance of Genome Resources, Apr 2022]

Rnf40 Products (1)

mRNA Protein Name
NM_153471.1 NP_703201.1 E3 ubiquitin-protein ligase BRE1B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12121982 RGD
enables syntaxin-1 binding IPI
IPI: Inferred from physical interaction
12121982 RGD
enables ubiquitin conjugating enzyme binding IDA
IDA: Inferred from direct assay
12121982 RGD
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
12121982 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of proteasomal protein catabolic process IDA
IDA: Inferred from direct assay
12121982 RGD
involved in positive regulation of protein polyubiquitination IDA
IDA: Inferred from direct assay
12121982 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
21734099 RGD
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
12121982 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
12121982 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase BRE1B

  • BRE1-B

  • RING-type E3 ubiquitin transferase BRE1B

  • protein staring

  • ring finger protein 40, E3 ubiquitin protein ligase

  • staring protein

  • syntaxin-1-interacting RING finger protein

Rnf40 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Rnf40 Q8CJB9 UBE2L6 Homo sapiens O14933
Anti Tag CoIP
12121982
Intra
Rnf40 Q8CJB9 Stx1b Rattus norvegicus P61265
Anti Tag CoIP
12121982
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W854844A (E)-JP-2-196 TFA Ligand 97.89% Unkown
HY-RS12091 RNF40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21037 Rnf40 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27554 Rnf40 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rnf40 NCBI NCBI:9810