DTD1 - D-aminoacyl-tRNA deacylase 1 Gene

Also Known as DTD; DUEB; DUE-B; HARS2; pqn-68; C20orf88

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 92675

About DTD1

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:18,588,054-18,766,644 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 7.0), brain (RPKM 6.2) and 25 other tissues.

Summary

The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

DTD1 Products (2)

mRNA Protein Name
NM_001318043.2 NP_001304972.1 D-aminoacyl-tRNA deacylase 1 isoform 1
NM_080820.6 NP_543010.3 D-aminoacyl-tRNA deacylase 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding EXP
EXP: Inferred from Experiment
17264083 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA duplex unwinding EXP
EXP: Inferred from Experiment
17264083 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DTD1 Protein Structure

Tyr_Deacylase

Tyr_Deacylase: D-Tyr-tRNA(Tyr) deacylase (2 - 146)

  • 0
  • 100
  • 209 a.a.
Protein Preferred Names Protein Names

D-aminoacyl-tRNA deacylase 1

  • D-tyrosyl-tRNA deacylase 1 homolog

Recombinant DTD1 Proteins

Cat. No. Product Name Accession Purity
HY-P70087 DTD1 Protein, Human (HEK293, His) Q8TEA8 (M1-P209) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Lipoid Proteinosis Of Urbach And Wiethe

  • Lipoid Proteinosis

  • Urbach-Wiethe Disease

  • Hyalinosis Cutis Et Mucosae

  • Lipid Proteinosis

  • Lipoproteinosis

  • Urbach Wiethe Disease

  • Lipoglycoproteinosis

  • Lipoidosis Cutis Et Mucosae

  • Lipoidproteinosis

  • Urbach-Wiethe Lipoid Proteinosis

  • Urbach-Wiethe Syndrome

  • LIP

  • Proteinosis Lipoid
Spinocerebellar Ataxia 10

  • Spinocerebellar Ataxia Type 10

  • SCA10

  • Spinocerebellar Ataxia-10

  • Ataxia, Spinocerebellar, Type 10
Ornithosis

  • Psittacosis

  • Chlamydial Pneumonia

  • Chlamydia Psittaci Infection

  • Chlamydia Psittaci
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04031 DTD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19128 Dtd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25618 Dtd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DTD1 VGNC VGNC:28228
Felis catus DTD1 VGNC VGNC:80088
Macaca mulatta DTD1 VGNC VGNC:84730
Canis familiaris DTD1 VGNC VGNC:103672
Mus musculus DTD1 MGD MGI:1913294
Rattus norvegicus DTD1 RGD RGD:1311821
Others DTD1 NCBI