DTD1 - D-aminoacyl-tRNA deacylase 1 Gene

Homo sapiens

Also known as DTD; DUEB; DUE-B; HARS2; pqn-68; C20orf88

Gene ID: 92675 | Gene type: protein coding

About DTD1

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:18,588,054-18,766,644 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 7.0), brain (RPKM 6.2) and 25 other tissues.

Summary

The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

DTD1 Products(2)

mRNA	Protein	Name
NM_001318043.2	NP_001304972.1	D-aminoacyl-tRNA deacylase 1 isoform 1
NM_080820.6	NP_543010.3	D-aminoacyl-tRNA deacylase 1 isoform 2

DTD1 Protein Structure

Tyr_Deacylase

0
100
209 a.a.

Protein Preferred Names

Protein Names

D-aminoacyl-tRNA deacylase 1

D-tyrosyl-tRNA deacylase 1 homolog

Recombinant DTD1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70087	DTD1 Protein, Human (HEK293, His)	Q8TEA8 (M1-P209)	≥95%

Related Diseases

Diseases

Alias

Lipoid Proteinosis Of Urbach And Wiethe

Lipoid Proteinosis	Urbach-Wiethe Disease
Hyalinosis Cutis Et Mucosae	Lipid Proteinosis
Lipoproteinosis	Urbach Wiethe Disease
Lipoglycoproteinosis	Lipoidosis Cutis Et Mucosae
Lipoidproteinosis	Urbach-Wiethe Lipoid Proteinosis
Urbach-Wiethe Syndrome	LIP
Proteinosis Lipoid

Spinocerebellar Ataxia 10

Spinocerebellar Ataxia Type 10	SCA10
Spinocerebellar Ataxia-10	Ataxia, Spinocerebellar, Type 10

Ornithosis

Psittacosis	Chlamydial Pneumonia
Chlamydia Psittaci Infection	Chlamydia Psittaci

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04031	DTD1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DTD1	VGNC	VGNC:28228
Felis catus	DTD1	VGNC	VGNC:80088
Macaca mulatta	DTD1	VGNC	VGNC:84730
Canis familiaris	DTD1	VGNC	VGNC:103672
Mus musculus	DTD1	MGD	MGI:1913294
Rattus norvegicus	DTD1	RGD	RGD:1311821
Others	DTD1	NCBI