Arid1a - AT rich interactive domain 1A (SWI-like) Gene

Also Known as Osa1; BAF250; BAF250a; Smarcf1; 1110030E03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 93760

Summary

Enables ATP-dependent chromatin remodeler activity. Contributes to nucleosome binding activity. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and toxin transport. Located in chromatin. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Used to study Coffin-Siris syndrome. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 2; breast cancer; carcinoma (multiple); gastrointestinal system Cancer (multiple); and neuroblastoma. Orthologous to human ARID1A (AT-rich interaction domain 1A). [provided by Alliance of Genome Resources, Apr 2022]

Arid1a Products (6)

mRNA Protein Name
NM_001080819.2 NP_001074288.1 AT-rich interactive domain-containing protein 1A isoform 1
NM_001363070.2 NP_001349999.1 AT-rich interactive domain-containing protein 1A isoform 2
NM_001401271.1 NP_001388200.1 AT-rich interactive domain-containing protein 1A isoform 3
NM_001401273.1 NP_001388202.1 AT-rich interactive domain-containing protein 1A isoform 4
NM_001401275.1 NP_001388204.1 AT-rich interactive domain-containing protein 1A isoform 2
NM_001401276.1 NP_001388205.1 AT-rich interactive domain-containing protein 1A isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent chromatin remodeler activity IDA
IDA: Inferred from direct assay
23129809 MGI
contributes to nucleosome binding IDA
IDA: Inferred from direct assay
23129809 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11988099 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cardiac chamber development IMP
IMP: Inferred from mutant phenotype
23129809 MGI
acts upstream of or within cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
24335282 MGI
acts upstream of or within chromatin organization IPI
IPI: Inferred from physical interaction
11318604 MGI
acts upstream of or within chromatin remodeling IMP
IMP: Inferred from mutant phenotype
18448678 MGI
acts upstream of or within embryo implantation IMP
IMP: Inferred from mutant phenotype
18448678 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
23129809 MGI
acts upstream of or within formation of primary germ layer IMP
IMP: Inferred from mutant phenotype
18448678 MGI
acts upstream of or within gastrulation IMP
IMP: Inferred from mutant phenotype
18448678 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
23129809 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24335282 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
23129809 MGI
acts upstream of or within optic cup formation involved in camera-type eye development IMP
IMP: Inferred from mutant phenotype
23129809 MGI
acts upstream of or within placenta blood vessel development IMP
IMP: Inferred from mutant phenotype
23129809 MGI
acts upstream of or within stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
18448678 MGI
Cellular Component GO Annotation Evidence References Source
part of SWI/SNF complex IDA
IDA: Inferred from direct assay
11318604 MGI
part of SWI/SNF superfamily-type complex IDA
IDA: Inferred from direct assay
12368262 MGI
located in chromatin IDA
IDA: Inferred from direct assay
23129809 MGI
part of nBAF complex IDA
IDA: Inferred from direct assay
17640523 MGI
part of npBAF complex IDA
IDA: Inferred from direct assay
17640523 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

AT-rich interactive domain-containing protein 1A

  • ARID domain-containing protein 1A

  • AT rich interactive domain 1A (Swi1 like)

  • BRG1-associated factor 250a

  • SWI-like protein

  • SWI/SNF complex protein p270

  • SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1

  • osa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114268 BRD-K98645985 Inhibitor 99.70% Unkown
HY-RS00966 ARID1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17472 Arid1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23930 Arid1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arid1a NCBI NCBI:8289