Smarca5 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 Gene

Also Known as Snf2h; MommeD4; 4933427E24Rik; D030040M08Rik; D330027N15Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 93762

Summary

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATP-dependent activity, acting on DNA. Predicted to contribute to histone binding activity. Involved in rDNA heterochromatin assembly. Acts upstream of or within cellular response to leukemia inhibitory factor; chromatin organization; and positive regulation of transcription, DNA-templated. Located in nucleus. Part of ISWI-type complex and chromatin silencing complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SMARCA5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5). [provided by Alliance of Genome Resources, Apr 2022]

Smarca5 Products (1)

mRNA	Protein	Name
NM_053124.2	NP_444354.2	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11980720	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in DNA methylation-dependent heterochromatin formation	IDA IDA: Inferred from direct assay	12198165	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
acts upstream of or within chromatin organization	IDA IDA: Inferred from direct assay	11980720	MGI
acts upstream of or within chromatin remodeling	IDA IDA: Inferred from direct assay	11980720	MGI
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	11980720	MGI
acts upstream of or within chromatin remodeling	IGI IGI: Inferred from genetic interaction	11532953	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	16880268	MGI
involved in heterochromatin formation	IDA IDA: Inferred from direct assay	16678107	MGI
involved in negative regulation of transcription by RNA polymerase I	IDA IDA: Inferred from direct assay	12368916	MGI
involved in positive regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	12434153	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16880268	MGI
involved in rDNA heterochromatin formation	IDA IDA: Inferred from direct assay	12198165	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of ISWI-type complex	IPI IPI: Inferred from physical interaction	22154806	MGI
part of NoRC complex	IPI IPI: Inferred from physical interaction	11532953	MGI
part of chromatin silencing complex	IDA IDA: Inferred from direct assay	16085498	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11980720	MGI
located in pericentric heterochromatin	IDA IDA: Inferred from direct assay	11980720	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5	mSnf2h sucrose nonfermenting protein 2 homolog

Smarca5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Smarca5	Q91ZW3	Maf	Mus musculus	P54843	Anti Bait CoIP	16675956
Intra	Smarca5	Q91ZW3	Maf	Mus musculus	P54843	Anti Tag CoIP	16675956
Intra	Smarca5	Q91ZW3	Baz1b	Mus musculus	Q9Z277	Anti Bait CoIP	11980720

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13406	SMARCA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21260	Smarca5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27779	Smarca5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smarca5	NCBI	NCBI:8467