Mgat2 - alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Gene

Also Known as Gnt2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 94273

About Mgat2

Primary_assembly 6: 87,656,349-87,658,177 forward strand.mRatBN7.2:CM026979.1

This gene has 1 transcript (splice variant), 178 orthologues and is associated with 10 phenotypes.

Summary

Enables alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity and carbohydrate binding activity. Involved in protein N-linked glycosylation. Predicted to be located in Golgi apparatus and cytoplasmic side of rough endoplasmic reticulum membrane. Predicted to be part of large ribosomal subunit. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIa. Orthologous to human MGAT2 (alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Mgat2 Products (1)

mRNA Protein Name
NM_053604.2 NP_446056.1 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IDA
IDA: Inferred from direct assay
2952645 RGD
enables carbohydrate binding IPI
IPI: Inferred from physical interaction
2952645 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mgat2 Protein Structure

MGAT2

MGAT2: pfam05060 (86 - 434)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 442 a.a.
Protein Preferred Names Protein Names

alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

  • GNT-II

  • N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II

  • beta-1,2-N-acetylglucosaminyltransferase II

  • beta-12-N-acetylglucosaminyltransferase II

  • glcNAc-T II

  • mannoside acetylglucosaminyltransferase 2

  • mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-159422 S-309309 Inhibitor 98.55% Phase 2

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-U00430 MGAT2-IN-2 Inhibitor / Unkown
HY-181563 MGAT2-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mgat2 NCBI NCBI:4247