Dpyd - dihydropyrimidine dehydrogenase Gene

Also Known as DPD; DHPDHase; E330028L06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 99586

Summary

Enables dihydropyrimidine dehydrogenase (NADP+) activity. Involved in pyrimidine nucleoside monophosphate catabolic process. Acts upstream of or within pyrimidine nucleobase catabolic process. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculature; and sensory organ. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic Cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Dpyd Products (1)

mRNA Protein Name
NM_170778.3 NP_740748.1 dihydropyrimidine dehydrogenase [NADP(+)]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables dihydropyrimidine dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
5472365 MGI
Biological Process GO Annotation Evidence References Source
involved in CMP catabolic process IDA
IDA: Inferred from direct assay
5472365 MGI
involved in UMP catabolic process IDA
IDA: Inferred from direct assay
5472365 MGI
involved in dCMP catabolic process IDA
IDA: Inferred from direct assay
5472365 MGI
involved in dUMP catabolic process IDA
IDA: Inferred from direct assay
5472365 MGI
acts upstream of or within pyrimidine nucleobase catabolic process IDA
IDA: Inferred from direct assay
12651209 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
5472365 MGI
located in cytosol IDA
IDA: Inferred from direct assay
12651209 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dihydropyrimidine dehydrogenase [NADP(+)]

  • dihydrothymine dehydrogenase

  • dihydrouracil dehydrogenase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17469 Gimeracil Inhibitor 99.81% Unkown

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03979 DPYD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W777340 Gimeracil-13C3 / Unkown
HY-17469S Gimeracil-13C3,15N / Unkown
HY-RS21328 Dpyd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27847 Dpyd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dpyd NCBI NCBI:1806