2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. GR119566X dihydrochloride

GR119566X dihydrochloride is a 5-HT3 receptor ligand with a pKi value of 8.80 against prufied 5-HT3 receptor. GR119566X dihydrochloride can be used for 5-HT3 receptor purification.

For research use only. We do not sell to patients.

GR119566X dihydrochloride

GR119566X dihydrochloride Chemical Structure

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Other Forms of GR119566X dihydrochloride:

GR119566X dihydrochloride Related Antibodies

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Description

GR119566X dihydrochloride is a 5-HT3 receptor ligand with a pKi value of 8.80 against prufied 5-HT3 receptor. GR119566X dihydrochloride can be used for 5-HT3 receptor purification[1].

IC50 & Target[1]

5-HT3 Receptor

 

In Vitro

GR119566X (12.5 mg; 16 h) is successfully coupled to Affi-Gel 15 to form an affinity resin that specifically retains solubilized 5-HT3 receptors from porcine cerebral cortex, enabling receptor purification[1].
GR119566X (60 min at 37°C) binds to membrane-bound, solubilized, and affinity-purified 5-HT3 receptors from porcine cerebral cortex with consistent high affinity, as shown by pKi values ranging from 8.21 to 8.80[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GR119566X dihydrochloride Related Antibodies
Molecular Weight

409.35

Formula

C20H26Cl2N4O
Appearance

Solid

SMILES

NCCCN1C(CCC(C2=O)CC3=C(N=CN3)C)=C2C4=C1C=CC=C4.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (244.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4429 mL 12.2145 mL 24.4290 mL
5 mM 0.4886 mL 2.4429 mL 4.8858 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4429 mL 12.2145 mL 24.4290 mL 61.0724 mL
5 mM 0.4886 mL 2.4429 mL 4.8858 mL 12.2145 mL
10 mM 0.2443 mL 1.2214 mL 2.4429 mL 6.1072 mL
15 mM 0.1629 mL 0.8143 mL 1.6286 mL 4.0715 mL
20 mM 0.1221 mL 0.6107 mL 1.2214 mL 3.0536 mL
25 mM 0.0977 mL 0.4886 mL 0.9772 mL 2.4429 mL
30 mM 0.0814 mL 0.4071 mL 0.8143 mL 2.0357 mL
40 mM 0.0611 mL 0.3054 mL 0.6107 mL 1.5268 mL
50 mM 0.0489 mL 0.2443 mL 0.4886 mL 1.2214 mL
60 mM 0.0407 mL 0.2036 mL 0.4071 mL 1.0179 mL
80 mM 0.0305 mL 0.1527 mL 0.3054 mL 0.7634 mL
100 mM 0.0244 mL 0.1221 mL 0.2443 mL 0.6107 mL
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GR119566X dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GR119566X5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptoraffinity resinporcine cerebral cortexaffinity purificationpig cerebral cortexA?-Gel 155-hydroxytryptamine3 (5-HT3) receptorInhibitorinhibitorinhibit

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