GR119566X dihydrochloride
Based on 1 Customer Validation
GR119566X dihydrochloride is a 5-HT3 receptor ligand with a pKi value of 8.80 against prufied 5-HT3 receptor. GR119566X dihydrochloride can be used for 5-HT3 receptor purification.
For research use only. We do not sell to patients.
- Formula: C20H26Cl2N4O
- Molecular Weight:409.35
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All 5-HT Receptor Isoforms
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Biological Activity
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5-HT3 Receptor |
GR119566X (12.5 mg; 16 h) is successfully coupled to Affi-Gel 15 to form an affinity resin that specifically retains solubilized 5-HT3 receptors from porcine cerebral cortex, enabling receptor purification[1].
GR119566X (60 min at 37°C) binds to membrane-bound, solubilized, and affinity-purified 5-HT3 receptors from porcine cerebral cortex with consistent high affinity, as shown by pKi values ranging from 8.21 to 8.80[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 409.35
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Formula C20H26Cl2N4O
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SMILES
NCCCN1C(CCC(C2=O)CC3=C(N=CN3)C)=C2C4=C1C=CC=C4.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (244.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4429 mL | 12.2145 mL | 24.4290 mL | 61.0724 mL |
| 5 mM | 0.4886 mL | 2.4429 mL | 4.8858 mL | 12.2145 mL | |
| 10 mM | 0.2443 mL | 1.2214 mL | 2.4429 mL | 6.1072 mL | |
| 15 mM | 0.1629 mL | 0.8143 mL | 1.6286 mL | 4.0715 mL | |
| 20 mM | 0.1221 mL | 0.6107 mL | 1.2214 mL | 3.0536 mL | |
| 25 mM | 0.0977 mL | 0.4886 mL | 0.9772 mL | 2.4429 mL | |
| 30 mM | 0.0814 mL | 0.4071 mL | 0.8143 mL | 2.0357 mL | |
| 40 mM | 0.0611 mL | 0.3054 mL | 0.6107 mL | 1.5268 mL | |
| 50 mM | 0.0489 mL | 0.2443 mL | 0.4886 mL | 1.2214 mL | |
| 60 mM | 0.0407 mL | 0.2036 mL | 0.4071 mL | 1.0179 mL | |
| 80 mM | 0.0305 mL | 0.1527 mL | 0.3054 mL | 0.7634 mL | |
| 100 mM | 0.0244 mL | 0.1221 mL | 0.2443 mL | 0.6107 mL |
GR119566X dihydrochloride Related Classifications
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