2. GPCR/G Protein
  3. Adenylate Cyclase
  4. Guanylyl imidodiphosphate lithium

Guanylyl imidodiphosphate lithium  (Synonyms: Gpp(NH)p lithium)

製品番号: HY-137167 純度: 99.86%
COA 取扱説明書 Technical Support

Guanylyl imidodiphosphate lithium (Gpp (NH) p lithium) is a non-hydrolyzable GTP analog. Guanylyl imidodiphosphate lithium increases adenylate cyclase activity. Guanylyl imidodiphosphate lithium binds to and irreversibly activates G proteins.

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Guanylyl imidodiphosphate lithium

Guanylyl imidodiphosphate lithium 構造式

CAS 番号 : 64564-03-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 823 在庫あり
Solution
10 mM * 1 mL in Water USD 823 在庫あり
Solid
1 mg $270 在庫あり
5 mg $685 在庫あり
10 mg $1100 在庫あり
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Other Forms of Guanylyl imidodiphosphate lithium:

Guanylyl imidodiphosphate lithium 関連抗体

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製品説明

Guanylyl imidodiphosphate lithium (Gpp (NH) p lithium) is a non-hydrolyzable GTP analog. Guanylyl imidodiphosphate lithium increases adenylate cyclase activity. Guanylyl imidodiphosphate lithium binds to and irreversibly activates G proteins[1][2][3].

体外実験

Guanylyl imidodiphosphate lithium (1 mM; 10 min) inhibits the incorporation of [α-32P]GTP into NDP kinase-related guanine nucleotide-binding proteins G1 (reduced to 17.5% of the control group) and G2 (reduced to 24.5% of the control group) derived from HeLa S3 cells[2].
Guanylyl imidodiphosphate lithium (1 mM; 20 min) inhibits the GTPase activity of NDP kinase-related guanine nucleotide-binding proteins G1 and G2 derived from HeLa S3 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Guanylyl imidodiphosphate lithium 関連抗体
分子量

545.93

分子式

C10H13Li4N6O13P3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](N[P](O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O)([H])N2C(NC(N)=NC3=O)=C3N=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : ≥ 50 mg/mL (91.59 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8317 mL 9.1587 mL 18.3174 mL
5 mM 0.3663 mL 1.8317 mL 3.6635 mL
10 mM 0.1832 mL 0.9159 mL 1.8317 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.86%

COA (251 KB) HNMR (444 KB) RP-HPLC (276 KB) MS (69 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8317 mL 9.1587 mL 18.3174 mL 45.7934 mL
5 mM 0.3663 mL 1.8317 mL 3.6635 mL 9.1587 mL
10 mM 0.1832 mL 0.9159 mL 1.8317 mL 4.5793 mL
15 mM 0.1221 mL 0.6106 mL 1.2212 mL 3.0529 mL
20 mM 0.0916 mL 0.4579 mL 0.9159 mL 2.2897 mL
25 mM 0.0733 mL 0.3663 mL 0.7327 mL 1.8317 mL
30 mM 0.0611 mL 0.3053 mL 0.6106 mL 1.5264 mL
40 mM 0.0458 mL 0.2290 mL 0.4579 mL 1.1448 mL
50 mM 0.0366 mL 0.1832 mL 0.3663 mL 0.9159 mL
60 mM 0.0305 mL 0.1526 mL 0.3053 mL 0.7632 mL
80 mM 0.0229 mL 0.1145 mL 0.2290 mL 0.5724 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Guanylyl imidodiphosphate lithium Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanylyl imidodiphosphate64564-03-0Gpp(NH)pAdenylate CyclaseAdenylyl cyclaseGTP analogadenylate cyclaseInhibitorinhibitorinhibit

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