1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. hCAI/II-IN-2

hCAI/II-IN-2 (compound 2b) is a potent dual hCA I/II inhibitor with Ki values of 40.97, 15.15 and 61.88 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-2 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity.

For research use only. We do not sell to patients.

hCAI/II-IN-2 Chemical Structure

hCAI/II-IN-2 Chemical Structure

CAS No. : 2480283-75-6

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Description

hCAI/II-IN-2 (compound 2b) is a potent dual hCA I/II inhibitor with Ki values of 40.97, 15.15 and 61.88 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-2 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity[1].

In Vitro

hCAI/II-IN-2 (compound 2b) (5-200 μM, 48 hours; HEK293T cells) has no obvious toxicity at HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: Embryonic kidney (HEK293T) cells
Concentration: 5, 25, 50, 100 and 200 μM
Incubation Time: 48 hours
Result: Had no apparent cytotoxicity.
In Vivo
Animal Model: Male BLAB/c mice[1]
Dosage: 400 mg/kg
Administration: Oral administration; 14 days.
Result: Prolonged the survival time of mice by 21.7% compared with the blank control group.
Molecular Weight

356.38

Formula

C12H12N4O5S2

CAS No.
SMILES

O=C(C1=NN=C(NC(C2=CC=C(S(=O)(N)=O)C=C2)=O)S1)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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hCAI/II-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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hCAI/II-IN-2
Cat. No.:
HY-147922
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