hCAI/II-IN-2
hCAI/II-IN-2 (compound 2b) is a potent dual hCA I/II inhibitor with Ki values of 40.97, 15.15 and 61.88 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-2 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity.
For research use only. We do not sell to patients.
- CAS No.: 2480283-75-6
- Formula: C12H12N4O5S2
- Molecular Weight:356.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
hCAI/II-IN-2 (compound 2b) (5-200 μM, 48 hours; HEK293T cells) has no obvious toxicity at HEK293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Embryonic kidney (HEK293T) cells
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Concentration:5, 25, 50, 100 and 200 μM
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Incubation Time:48 hours
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Result:Had no apparent cytotoxicity.
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Animal Model:Male BLAB/c mice[1]
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Dosage:400 mg/kg
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Administration:Oral administration; 14 days.
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Result:Prolonged the survival time of mice by 21.7% compared with the blank control group.
Chemical Information
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CAS No. 2480283-75-6
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Molecular Weight 356.38
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Formula C12H12N4O5S2
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SMILES
O=C(C1=NN=C(NC(C2=CC=C(S(=O)(N)=O)C=C2)=O)S1)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCAI/II-IN-2 Related Classifications
HY-147922 Related Classifications
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