Immethridine dihydrobromide
Based on 1 Customer Validation
Immethridine (dihydrobromide) is a potent and highly selective histamine H3 receptor agonist with pKi and pEC50 value of 9.07 and 9.74, respectively. Immethridine can be used for the research of myocardial ischemia, inflammatory, and gastric acid related diseases research.
For research use only. We do not sell to patients.
- Purity : 99.61%
- CAS No.: 699020-93-4
- Formula: C9H11Br2N3
- Molecular Weight:321.01
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Histamine Receptor Isoforms
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Biological Activity
Description
IC50 & Target
pKi: 9.07, pEC50: 9.74 (histamine H(3) receptor)[1]
Chemical Information
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CAS No. 699020-93-4
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Appearance Solid
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Molecular Weight 321.01
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Formula C9H11Br2N3
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Color Off-white to light yellow
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SMILES
[H]Br.[H]Br.C1(CC2=CN=CN2)=CC=NC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
H2O : 15 mg/mL (46.73 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Shi Y, et al. Immethridine, histamine H3-receptor (H3R) agonist, alleviated experimental autoimmune encephalomyelitis via inhibiting the function of dendritic cells. Oncotarget. 2017 Aug 24;8(43):75038-75049. [Content Brief]
[2]. Kitbunnadaj R, et al. Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist. J Med Chem. 2004 May 6;47(10):2414-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.1152 mL | 15.5758 mL | 31.1517 mL | 77.8792 mL |
| 5 mM | 0.6230 mL | 3.1152 mL | 6.2303 mL | 15.5758 mL | |
| 10 mM | 0.3115 mL | 1.5576 mL | 3.1152 mL | 7.7879 mL | |
| 15 mM | 0.2077 mL | 1.0384 mL | 2.0768 mL | 5.1919 mL | |
| 20 mM | 0.1558 mL | 0.7788 mL | 1.5576 mL | 3.8940 mL | |
| 25 mM | 0.1246 mL | 0.6230 mL | 1.2461 mL | 3.1152 mL | |
| 30 mM | 0.1038 mL | 0.5192 mL | 1.0384 mL | 2.5960 mL | |
| 40 mM | 0.0779 mL | 0.3894 mL | 0.7788 mL | 1.9470 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Immethridine dihydrobromide Related Classifications
HY-108058A Related Classifications
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