BUB
The BUB family contributes two large checkpoint kinases with partly overlapping duties. BUB1 is recruited to unattached kinetochores through BUB3 and phosphorylates histone H2A at Thr120, creating a platform for shugoshin and the chromosome passenger complex, while its C-terminal region aids mitotic checkpoint complex assembly. BUBR1 (BUB1B) also binds BUB3 and Cdc20; although its intrinsic kinase activity is weak, it is essential for checkpoint-mediated inhibition of the APC/C. Reduced BUBR1 causes mosaic variegated aneuploidy syndrome and premature-aging phenotypes in mice, and loss of BUB1 function drives chromosome instability in tumors. Both proteins are attractive but technically difficult therapeutic targets.
-
BUB Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
