AMX12006
Based on 1 Customer Validation
AMX12006 is a potent, selective and orally active EP4 antagonist with an IC50 value of 4.3 nM. AMX12006 shows cytotoxic and antitumor activity.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 2639775-01-0
- Formula: C26H22F3N3O3
- Molecular Weight:481.47
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hEP4 4.3 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
79.47 μM
Compound: 36; AMX12006
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Cytotoxicity against mouse 4T1 cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay
Cytotoxicity against mouse 4T1 cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay
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[PMID: 37312837] |
| CT26.WT | IC50 |
41.39 μM
Compound: 36; AMX12006
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Cytotoxicity against mouse CT26.WT cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay
Cytotoxicity against mouse CT26.WT cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay
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[PMID: 37312837] |
| Lewis lung carcinoma cell line | IC50 |
>100 μM
Compound: 36; AMX12006
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Cytotoxicity against mouse Lewis lung carcinoma cell line assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay
Cytotoxicity against mouse Lewis lung carcinoma cell line assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay
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[PMID: 37312837] |
| MCF7 | IC50 |
46.73 μM
Compound: 36; AMX12006
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Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay
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[PMID: 37312837] |
AMX12006 (compound 36) (0-100 µM) shows cytotoxic with IC50s of 46.73, 79.47, >100, 41.39, >100 µM for MCF-7, 4T1, HCA-7, CT-26 WT, LLC cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, 4T1, HCA-7, CT-26 WT, LLC cells
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Concentration:0-100 µM
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Incubation Time:
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Result:Showed cytotoxic with IC50s of 46.73, 79.47, >100, 41.39, >100 µM for MCF-7, 4T1, HCA-7, CT-26 WT, LLC cells, respectively.
Pharmacokinetic Parameters of AMX12006 in Sprague-Dawley rats[1].
| iv, 1 mg/kg | po, 10 mg/kg | |
| Tmax (h) | 0.5 | |
| Cmax (ng/mL) | 4627 ± 304 | 8243 ± 370 |
| AUC(0-t)(h·ng/mL) | 3375 ± 477 | 25672 ± 5668 |
| AUC0–∞ (h·ng/mL) | 3416 ± 495 | 25707 ± 5682 |
| T1/2(h) | 1.4 ± 0.3 | 2.7 ± 0.2 |
| CL (mL/min/kg) | 4.95 ± 0.77 | |
| Vdss (L/kg) | 0.41 ± 0.04 | |
| F % | 76.1 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2639775-01-0
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Appearance Solid
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Molecular Weight 481.47
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Formula C26H22F3N3O3
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Color White to light yellow
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SMILES
O=C(N[C@@H](C)C1=CC=C(C(O)=O)C=C1)C2=C(C3=CC=CC=C3N2C)NC4=CC(C(F)(F)F)=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMF : 20 mg/mL (41.54 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 2.0770 mL | 10.3849 mL | 20.7697 mL | 51.9243 mL |
| 5 mM | 0.4154 mL | 2.0770 mL | 4.1539 mL | 10.3849 mL | |
| 10 mM | 0.2077 mL | 1.0385 mL | 2.0770 mL | 5.1924 mL | |
| 15 mM | 0.1385 mL | 0.6923 mL | 1.3846 mL | 3.4616 mL | |
| 20 mM | 0.1038 mL | 0.5192 mL | 1.0385 mL | 2.5962 mL | |
| 25 mM | 0.0831 mL | 0.4154 mL | 0.8308 mL | 2.0770 mL | |
| 30 mM | 0.0692 mL | 0.3462 mL | 0.6923 mL | 1.7308 mL | |
| 40 mM | 0.0519 mL | 0.2596 mL | 0.5192 mL | 1.2981 mL |
AMX12006 Related Classifications
HY-149290 Related Classifications
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