NOL7 - nucleolar protein 7 Gene

Also Known as PQBP3; RARG-1; C6orf90; dJ223E5.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51406

About NOL7

Cytogenetic location: 6p23 Genomic coordinates (GRCh38): 6:13,615,335-13,632,470 (from NCBI)

This gene has 3 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in testis (RPKM 25.5), thyroid (RPKM 22.2) and 25 other tissues.

Summary

The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

NOL7 Products (2)

mRNA Protein Name
NM_001317724.2 NP_001304653.1 nucleolar protein 7
NM_016167.5 NP_057251.2 nucleolar protein 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in maturation of SSU-rRNA IMP
IMP: Inferred from mutant phenotype
37246770 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence References Source
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOL7 Protein Structure

NUC129

NUC129: NUC129 domain (172 - 234)

  • 0
  • 100
  • 200
  • 257 a.a.
Protein Preferred Names Protein Names

nucleolar protein 7

  • nucleolar protein 7, 27kDa

NOL7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NOL7 Q9UMY1 CCNDBP1 Homo sapiens O95273
Y2H Array
32296183
Intra
NOL7 Q9UMY1 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Renpenning Syndrome 1

  • Renpenning Syndrome

  • Golabi-Ito-Hall Syndrome

  • Mrxs3

  • Mrxs8

  • X-Linked Intellectual Disability Due To Pqbp1 Mutations

  • RENS1

  • Sutherland-Haan X-Linked Mental Retardation Syndrome

  • Shs

  • Mrx55

  • X-Linked Intellectual Disability, Renpenning Type

  • Sutherland-Haan Syndrome

  • Mental Retardation, X-Linked, Renpenning Type

  • Mental Retardation, X-Linked, With Spastic Diplegia

  • Mental Retardation, X-Linked, Syndromic 3

  • Mental Retardation, X-Linked, Syndromic 8

  • Mental Retardation, X-Linked 55

  • Syndromic X-Linked Mental Retardation 8

  • X-Linked Mental Retardation Renpenning Type

  • X-Linked Mental Retardation With Spastic Diplegia

  • Sutherland-Haan X-Linked Intellectual Disability Syndrome

  • X-Linked Intellectual Disability With Spastic Diplegia

  • Hamel Cerebropalatocardiac Syndrome

  • Porteous Syndrome

  • X-Linked Intellectual Deficit Due To Pqbp1 Mutations

  • X-Linked Intellectual Deficit, Renpenning Type

  • X-Linked Intellectual Disability, Sutherland-Haan Type

  • Hamel Cerebro-Palato-Cardiac Syndrome

  • Renpenning Syndrome, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09417 NOL7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NOL7 VGNC VGNC:32159
Macaca mulatta NOL7 VGNC VGNC:75226
Mus musculus NOL7 MGD MGI:1917328
Rattus norvegicus NOL7 RGD RGD:1565934
Canis familiaris NOL7 VGNC VGNC:43884
Felis catus NOL7 VGNC VGNC:102476
Others NOL7 NCBI