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Cat. No.: HY-117476

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Sapelin B

Sapelin B is a naturally occurring tirucallane-type triterpenoid that exhibits in vivo antitumor activity in a mouse model of P-388 lymphocytic leukemia. Sapelin B can be used in leukemia-related research.

For research use only. We do not sell to patients.

CAS No.: 26790-94-3
Formula: C₃₀H₅₀O₄
Molecular Weight:474.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Sapelin B Chemical Structure

CAS No.: 26790-94-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Protocols (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	10 μM Compound: 26	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
A549	IC₅₀	>10 μM Compound: 26	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
MCF7	IC₅₀	>10 μM Compound: 26	Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
MCF7	IC₅₀	10 μM Compound: 26	Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
MKN-28	IC₅₀	>10 μM Compound: 26	Cytotoxicity against human MKN28 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MKN28 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
MKN-28	IC₅₀	10 μM Compound: 26	Cytotoxicity against human MKN28 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MKN28 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]

In Vivo

Sapelin B (1.25-10.0 mg/kg) exhibits in vivo antitumor activity in the P-388 lymphocytic leukemia mouse model, with T/C survival ratios ≥ 125% across all tested doses^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 26790-94-3
Molecular Weight 474.72
Formula C₃₀H₅₀O₄
SMILES

CC1([C@@H](CC[C@@]2([C@]3(CC[C@]4([C@](CC[C@@]4(C3=CC[C@@]12[H])C)([H])[C@@]5([H])COC(C)(C)[C@@H](O)[C@H](O)C5)C)[H])C)O)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
How to Choose the Right Model Animal
Choosing the right model animal is a validity-driven decision in which the species, strain, sex, age, genetic background, disease-induction method, outcome measures, and welfare burden must match the scientific question rather than laboratory tradition or convenience. A model should be selected by judging face validity, construct validity, and predictive validity: whether it resembles the human phenotype, whether it reproduces relevant mechanisms, and whether results are likely to predict human biology or treatment response. Animal studies often fail to translate because of species differences, weak disease resemblance, poor experimental design, inadequate reporting, publication bias, and underuse of randomization, blinding, and sample-size justification. Unresolved questions include how to rank competing models objectively, how much human-disease complexity must be reproduced for a given objective, and when non-animal systems such as organoids, ex vivo tissue, or computational models

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu W B, et al. New triterpenoids with protein tyrosine phosphatase 1B inhibition from Cedrela odorata. Journal of Asian Natural Products Research, 2014, 16(7): 709-716.

[2]. Jolad SD, et al. Cytotoxic agents from Bursera klugii (Burseraceae) I: isolation of sapelins A and B. Journal of pharmaceutical sciences. 1977 Jun;66(6):889-90. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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