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Cat. No.: HY-P11867

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UM206_L

UM206_L is a linear Wnt fragment peptide derived from conserved Wnt3a/Wnt5a sequences, inactive in soluble form but capable of activating canonical Wnt/β-catenin signaling when conjugated to magnetic nanoparticles and exposed to a high-gradient, time-varying magnetic field or immobilized on glass surfaces.

For research use only. We do not sell to patients.

CAS No.: 1242439-00-4
Formula: C₅₄H₉₀N₁₆O₂₃S₃
Molecular Weight:1427.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

UM206_L Chemical Structure

CAS No.: 1242439-00-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

All Wnt Isoforms :

In Vitro

UM206_L (free form) (10 nM-1 mM; 3 h, 24 h) fails to stably regulate the canonical Wnt/β-catenin TCF/LEF signaling pathway in HEK293 Luc-TCF/LEF cells^[1].
UM206_L-conjugated MNPs (1-10 µg per mg MNP; 1-24 h), when combined with 1 Hz nanomagnetic actuation, potently activate the canonical Wnt/β-catenin TCF/LEF signaling pathway in HEK293 Luc-TCF/LEF cells in a peptide density-dependent manner in vitro^[1].
UM206_L (immobilized; 1 µg per slide; 3-24 h) retains weak canonical Wnt/β-catenin TCF/LEF signaling activity in HEK293 Luc-TCF/LEF cells on glass substrates, induces a significant increase in signaling at 3 h, and this signaling level is maintained until 24 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1242439-00-4
Molecular Weight 1427.58
Formula C₅₄H₉₀N₁₆O₂₃S₃
Sequence

Ac-Cys-Asn-Lys-Thr-Ser-Glu-Gly-Met-Asp-Gly-Cys-Glu-Leu-NH2
Sequence Shortening

Ac-CNKTSEGMDGCEL-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hu B, et al. Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics. Int J Mol Sci. 2022;23(17):10164. Published 2022 Sep 5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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UM206_L

All Wnt Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

UM206_L Related Classifications

HY-P11867 Related Classifications