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Cat. No.: HY-145336

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JAK1/TYK2-IN-1

JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 (IC₅₀ = 29 and 41 nM respectively).

For research use only. We do not sell to patients.

CAS No.: 1883300-48-8
Formula: C₁₈H₂₀F₃N₇O
Molecular Weight:407.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

JAK1/TYK2-IN-1 Chemical Structure

CAS No.: 1883300-48-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 (IC₅₀ = 29 and 41 nM respectively).

All JAK Isoforms :

Chemical Information

CAS No. 1883300-48-8
Molecular Weight 407.39
Formula C₁₈H₂₀F₃N₇O
SMILES

O=C([C@H]1C(F)(C1)F)N[C@]23[C@](CN(C4=NC(NC5=CN(C)N=C5)=NC=C4F)C3)([H])[C@H]2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fensome A, et al. Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1. Bioorg Med Chem. 2020 May 15;28(10):115481. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
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References

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JAK1/TYK2-IN-1

All JAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JAK1/TYK2-IN-1 Related Classifications

HY-145336 Related Classifications