JNJ-DGAT2-A 

JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC₅₀ value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis^[1].

IC50: 0.14 μM (Sf9 insect cell membranes DGAT2)^[1]

JNJ-DGAT2-A (5 μM) inhibits about 99% of recombinant DGAT2 enzymatic activity^[1].
JNJ-DGAT2-A (5 μM) inhibits the DGAT activity in HepG2 cell lysates^[1].
JNJ-DGAT2-A (0.3125, 0.625, 1.25, 2.5, 5, 10, and 20 µM; 60 min prior to isotope-labeled and additional 2 h after isotope-labeled) dose-dependently inhibits the generation of TG (52:2), TG (54:3), and TG (50:2) using ¹³C3-D5-glycerol as a substrate in HepG2 cells with IC₅₀ values of 0.85 μM, 0.99 μM, and 0.66 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

523.38

C₂₄H₁₆BrFN₄O₂S

1962931-71-0

Solid

Light yellow to yellow

BrC1=C(C=CC(C#N)=C1)OC2=C(C=C(C=C2)/C=C3SC(NCCC4=CC=CC=N4)=NC\3=O)F

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Qi J, et al. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2. J Lipid Res. 2012 Jun;53(6):1106-16.  [Content Brief]