2. MAPK/ERK Pathway
  3. JNK
  4. JNK3 inhibitor-7

JNK3 inhibitor-7 is a potent, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 53, 973, 1039 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-7 shows significant neuroprotective effects. JNK3 inhibitor-7 has the potential for the research of Alzheimer’s disease (AD).

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JNK3 inhibitor-7

JNK3 inhibitor-7 構造式

CAS 番号 : 3034676-52-0

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JNK3 inhibitor-7 関連抗体

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製品説明

JNK3 inhibitor-7 is a potent, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 53, 973, 1039 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-7 shows significant neuroprotective effects. JNK3 inhibitor-7 has the potential for the research of Alzheimer’s disease (AD)[1].

IC50 & Target[1]

JNK3

53 nM (IC50)

JNK2

973 nM (IC50)

JNK1

1039 nM (IC50)

体外実験

JNK3 inhibitor-7 (compound 2h; 20 µM; 24, 48 h) increases primary rat cortex neuron cell viability when treatment with 10 μM amyloid-β1-42[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNK3 inhibitor-7 関連抗体

Cell Viability Assay[1]

Cell Line: primary rat cortex neuron cells
Concentration: 20 µM
Incubation Time: 24, 48 h
Result: Increased cell viability when treatment with 10 μM amyloid-β1-42.
体内実験

JNK3 inhibitor-7 (30, 60 mg/kg; p.o.; daily for 4 weeks) shows significant neuroprotective effects in mice[1].
Pharmacokinetic Parameters of JNK3 inhibitor-7 in Sprague-Dawley rats[1].

compound 2h
admin. PO
dose (mg/kg) 3
AUClast (h ng/ml) 350.68
C0 or Cmax (ng/mL) 342.30
Tmax (h) 0.39
T1/2 (h) 0.65
Sprague-Dawley rats, 3 mg/kg p.o.[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 7 month-old APP/PS1 AD mice[1]
Dosage: 30, 60 mg/kg
Administration: P.o.; daily for 4 weeks
Result: Decreased the escape time and distance traveled, a dose-dependent increased in the quadrant where the escape zone was located and the time spent.
分子量

561.63

分子式

C32H31N7O3
CAS 番号
SMILES

CNC(OC1=CC=C2N=C(C3=CC4=C(C=CC=C4)C=C3)N(C5=NC(N[C@@H]6CN(CCC6)C(C7CC7)=O)=NC=C5)C2=C1)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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JNK3 inhibitor-7 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK3 inhibitor-73034676-52-0JNKc-Jun N-terminal kinaseorally activecross the blood-brain barrierAlzheimer’s diseaseneuroprotectiveInhibitorinhibitorinhibit

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製品名:
JNK3 inhibitor-7
製品番号:
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