TRIR - telomerase RNA component interacting RNase Gene

Also Known as TERCIR; fSAP18; C19orf43

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79002

About TRIR

This gene has 5 transcripts (splice variants) and 177 orthologues. Ubiquitous expression in fat (RPKM 63.1), colon (RPKM 57.1) and 25 other tissues.

Summary

Enables 3'-5' exonuclease activity and 5'-3' exonuclease activity. Involved in RNA phosphodiester bond hydrolysis, exonucleolytic and rRNA catabolic process. [provided by Alliance of Genome Resources, Apr 2022]

TRIR Products (3)

mRNA	Protein	Name
NM_001329738.2	NP_001316667.1	telomerase RNA component interacting RNase isoform 2
NM_001329739.2	NP_001316668.1	telomerase RNA component interacting RNase isoform 3
NM_024038.4	NP_076943.1	telomerase RNA component interacting RNase isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables 3'-5' exonuclease activity	IDA IDA: Inferred from direct assay	28322335	GOA
enables 5'-3' exonuclease activity	IDA IDA: Inferred from direct assay	28322335	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in rRNA catabolic process	IDA IDA: Inferred from direct assay	28322335	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
telomerase RNA component interacting RNase	My029 protein

TRIR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIR	Q9BQ61	SNRPA	Homo sapiens	P09012	Y2H Prey Pooling	32296183
Intra	TRIR	Q9BQ61	SNRPA	Homo sapiens	P09012	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Arthrogryposis, Distal, Type 6	Distal Arthrogryposis Type 6 DA6 Arthrogryposis-Like Hand Anomaly-Sensorineural Deafness Syndrome Arthrogryposis And Sensorineural Deafness Familial Hand Abnormality And Sensori-Neural Deafness Arthrogryposis-Like Hand Anomaly And Sensorineural Deafness Arthrogryposis-Like Hand Anomaly-Sensorineural Hearing Loss Syndrome
Binocular Vision Disease	Simultaneous Visual Perception Without Fusion
Tinea Unguium	Dermatophytosis Of Nail Onychomycosis Due To Dermatophyte Cellulitis And Abscess Cellulitis And Abscess Of Buttock Cellulitis And Abscess Of Face Cellulitis And Abscess Of Finger Cellulitis And Abscess Of Finger And Toe Cellulitis And Abscess Of Gluteal Region Cellulitis And Abscess Of Trunk Cellulitis And Abscess Of Upper Arm And Forearm Dermatophytic Onychia Dermatophytic Onychomycosis Onychomycosis Ringworm Of Nails Tinea Of Nail
Thiamine-Responsive Megaloblastic Anemia Syndrome	TRMA Rogers Syndrome Thiamine-Responsive Myelodysplasia Thiamine-Responsive Anemia Syndrome Thiamine Metabolism Dysfunction Syndrome 1 Thmd1 Megaloblastic Anemia, Thiamine-Responsive, With Diabetes Mellitus And Sensorineural Deafness Thiamine-Responsive Megaloblastic Anemia With Diabetes Mellitus And Sensorineural Deafness Thiamine Responsive Megaloblastic Anemia Syndrome Megaloblastic Anemia Thiamine-Responsive With Diabetes Mellitus And Sensorineural Deafness Thiamine-Responsive Megaloblastic Anemia Thiamine-Responsive Anaemia Syndrome Thiamine-Responsive Megaloblastic Anaemia Syndrome Thiamine-Responsive Megaloblastic Anaemia With Diabetes Mellitus And Sensorineural Deafness Thiamine-Responsive Megaloblastic Anemia With Diabetes Mellitus And Sensorineural Hearing Loss

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15083	TRIR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22350	Trir Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28872	Trir Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRIR	RGD	RGD:1564093
Bos taurus	TRIR	VGNC	VGNC:36362
Mus musculus	TRIR	MGD	MGI:1922833
Canis familiaris	TRIR	VGNC	VGNC:54381
Felis catus	TRIR	VGNC	VGNC:80747
Macaca mulatta	TRIR	VGNC	VGNC:79710
Others	TRIR	NCBI