製品番号: HY-N3017

Artemitin

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED₅₀ of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED₅₀ of 1.6 μg/kg, and has analgesic activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.97%
CAS 番号: 479-90-3
分子式: C₂₀H₂₀O₈
分子量:388.37

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Artemitin 構造式

CAS 番号: 479-90-3

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
Publications (1)
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Antibiotic アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	2200 ng/mL Compound: 10	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 11975496]
HepG2	IC₅₀	229 μM Compound: Artemetin	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 31784199]
HL-60	IC₅₀	6.44 μM Compound: VIII, 5-demethylhexaMF	Antiproliferative activity against HL60 after 24 hrs Antiproliferative activity against HL60 after 24 hrs	[PMID: 17391969]
Neutrophil	IC₅₀	>10 μg/mL Compound: 9	Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release using Meo-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate incubated for 5 mins prior to FMLP/CB-challenge by spectrophotometry Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release using Meo-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate incubated for 5 mins prior to FMLP/CB-challenge by spectrophotometry	[PMID: 22429052]
Neutrophil	IC₅₀	>10 μg/mL Compound: 9	Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide-anion generation incubated for 5 mins prior to FMLP/CB-challenge measured after 10 mins by spectrophotometry Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide-anion generation incubated for 5 mins prior to FMLP/CB-challenge measured after 10 mins by spectrophotometry	[PMID: 22429052]
PC-12	GI₅₀	2270 ng/mL Compound: 10	Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 11975496]
SH-SY5Y	IC₅₀	229 μM Compound: Artemetin	Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay	[PMID: 31784199]

体外実験

Artemitin (10 μg/mL; 48 h) shows moderate cytotoxicity against Meth-A sarcoma cells with an ED₅₀ of 5-10 μg/mL, without significant cytotoxicity against LLC lung cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Meth-A sarcoma cells, LLC lung carcinoma cells
Concentration:

5-10 μg/mL
Incubation Time:

48 h
Result:

Dose-dependent growth inhibition against Meth-A cells, with ED₅₀ values ranging from 5 to 10 μg/ml, while no significant cytotoxic effects were observed in LLC cells under the same conditions.

体内実験

The peak concentration of Artemitin (10 mg/kg; tail vein injection; single dose; monitoring 0.08-6 h after administration) in the plasma of male SD rats is 0.08 h after administration (C_max=487.6 μg/L)^[2].
Artemitin (1.6 μg/kg; ip; single dose; observation 60 min after administration) significantly prolongs the latency of pain response in the hot plate model of male mice, showing a dose-dependent antinociceptive effect^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Pharmacokinetic study in Male SD rats (150-200 g)^[2]
Dosage:

10 mg/kg
Administration:

Tail vein injection, single dose, blood samples collected at 0.08, 0.17, 0.33, 0.5, 0.75, 1, 2, 3, 4, and 6 h post-administration
Result:

After a single intravenous dose of 10 mg/kg, Artemitin rapidly distributed in rats with C_max achieved at 0.08 h (487.6 μg/L).
The pharmacokinetic parameters were calculated using a two-compartment model, including AUC_(0-t)=862.403 μg/L·h, AUC_(0-∞)=929.84 μg/L·h), and T_1/2=1.556 h, indicating rapid elimination with measurable plasma concentrations up to 6 h.

化学情報

CAS 番号 479-90-3
性状 Solid
分子量 388.37
分子式 C₂₀H₂₀O₈
Color White to yellow
SMILES

O=C1C2=C(O)C(OC)=C(OC)C=C2OC(C3=CC(OC)=C(OC)C=C3)=C1OC
Structure Classification
- Flavonoids
- Flavonols
- Phenols
- Monophenols
Initial Source
- Plants
- other families
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

All

Sort by:

Journal Impact Factor

Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

溶剤 & 溶解度

体外:

DMSO : 50 mg/mL (128.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5749 mL

12.8743 mL

25.7486 mL

5 mM

0.5150 mL

2.5749 mL

5.1497 mL

10 mM

0.2575 mL

1.2874 mL

2.5749 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ma CM, et al. Triterpenes and lignans from Artemisia caruifolia and their cytotoxic effects on meth-A and LLC tumor cell lines. Chem Pharm Bull (Tokyo). 2001 Feb;49(2):183-7. [Content Brief]

[2]. Han X, et al. Development of an LC-MS/MS-based assay to determine artemitin in rat plasma and its application in a pharmacokinetic study. Biomed Chromatogr. 2018 Dec;32(12):e4356. [Content Brief]

[3]. Qnais, Esam, et al. Antinociceptive effect of two flavonoids from Aloysia triphylla L. Jordan Journal of Biological Sciences 2.4 (2009): 167-170.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5749 mL	12.8743 mL	25.7486 mL	64.3716 mL
	5 mM	0.5150 mL	2.5749 mL	5.1497 mL	12.8743 mL
	10 mM	0.2575 mL	1.2874 mL	2.5749 mL	6.4372 mL
	15 mM	0.1717 mL	0.8583 mL	1.7166 mL	4.2914 mL
	20 mM	0.1287 mL	0.6437 mL	1.2874 mL	3.2186 mL
	25 mM	0.1030 mL	0.5150 mL	1.0299 mL	2.5749 mL
	30 mM	0.0858 mL	0.4291 mL	0.8583 mL	2.1457 mL
	40 mM	0.0644 mL	0.3219 mL	0.6437 mL	1.6093 mL
	50 mM	0.0515 mL	0.2575 mL	0.5150 mL	1.2874 mL
	60 mM	0.0429 mL	0.2146 mL	0.4291 mL	1.0729 mL
	80 mM	0.0322 mL	0.1609 mL	0.3219 mL	0.8046 mL
	100 mM	0.0257 mL	0.1287 mL	0.2575 mL	0.6437 mL

Keywords

Artemitin

1 Cited Publications

100 mg お問い合わせ

Subscribe to the

MedChemExpress

Newsletter

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

Artemitin

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Natural Product Library

Medicine Food Homology Compound Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

Antibiotics Library

Flavonoids Library

Neuroprotective Compound Library

Anti-Lung Cancer Compound Library

Food-Sourced Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Mass Spectrometry Natural Product Library

MedChemExpress（MCE）の使用を引用している文献 Artemitin

Antibiotic アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Artemitin 関連分類

HY-N3017 関連分類