479-90-3
Chemical Structure
Artemitin
- CAS No.: 479-90-3
- Formula:C20H20O8
- Molecular Weight:388.37
IUPAC Name: 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-chromen-4-one
InChIKey: RIGYMJVFEJNCKD-UHFFFAOYSA-N
SMILES: O=C1C2=C(O)C(OC)=C(OC)C=C2OC(C3=CC(OC)=C(OC)C=C3)=C1OC
Biological Activity: Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED50 of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED50 of 1.6 μg/kg, and has analgesic activity[1][2][3].
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Artemitin | 99.97% | Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED50 of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED50 of 1.6 μg/kg, and has analgesic activity. | ||||||||||||||||||||
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Artemitin (Standard) | ≥98% | Artemitin (Standard) is the analytical standard of Artemitin. This product is intended for research and analytical applications. Artemitin is a flavonol found in Laggera pterodonta (DC.) Benth., with antioxidative, anti-inflammatory, and antiviral activity. | ||||||||||||||||||||
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References
- [1]. Ma CM, et al. Triterpenes and lignans from Artemisia caruifolia and their cytotoxic effects on meth-A and LLC tumor cell lines. Chem Pharm Bull (Tokyo). 2001 Feb;49(2):183-7. [Content Brief]
- [2]. Han X, et al. Development of an LC-MS/MS-based assay to determine artemitin in rat plasma and its application in a pharmacokinetic study. Biomed Chromatogr. 2018 Dec;32(12):e4356. [Content Brief]
- [3]. Qnais, Esam, et al. Antinociceptive effect of two flavonoids from Aloysia triphylla L. Jordan Journal of Biological Sciences 2.4 (2009): 167-170.
