479-90-3
479-90-3
Chemical Structure
Artemitin
- CAS No.: 479-90-3
- Formula:C20H20O8
- Molecular Weight:388.37
IUPAC Name: 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-chromen-4-one
InChIKey: RIGYMJVFEJNCKD-UHFFFAOYSA-N
SMILES: O=C1C2=C(O)C(OC)=C(OC)C=C2OC(C3=CC(OC)=C(OC)C=C3)=C1OC
Biological Activity: Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED50 of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED50 of 1.6 μg/kg, and has analgesic activity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Artemitin | 99.97% | Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED50 of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED50 of 1.6 μg/kg, and has analgesic activity. | ||||||||||||||||||||
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Artemitin (Standard) | ≥98% | Artemitin (Standard) is the analytical standard of Artemitin. This product is intended for research and analytical applications. Artemitin is a flavonol found in Laggera pterodonta (DC.) Benth., with antioxidative, anti-inflammatory, and antiviral activity. | ||||||||||||||||||||
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Casticin | 99.68% | Casticin is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3. | ||||||||||||||||||||
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5-Hydroxy-3,6,7,4'-tetramethoxyflavone | 99.76% | 5-Hydroxy-3,6,7,4'-tetramethoxyflavone is a natural compound isolated from Aglaia edulis. | ||||||||||||||||||||
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Brickellin | Brickellin is an antioxidant agent that can be isolated from Varronia curassavica Jacq.. Brickellin inhibits advanced glycation end products (AGEs) formation, protein crosslinking, and oxidative damage to proteins. Brickellin can be used for the research of diabetes. | |||||||||||||||||||||
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5,6-Dihydroxy-3,7,3',4'-tetramethoxyflavone | 5,6-Dihydroxy-3,7,3',4'-tetramethoxyflavone is a natural flavonoid. | |||||||||||||||||||||
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Chrysosplenetin | 99.84% | Chrysosplenetin is an orally active polymethoxyflavone. Chrysosplenetin exerts anticancer effects by inhibiting topoisomerase, protecting DNA and inducing apoptosis. Chrysosplenetin acts as an antimalarial sensitizer, reverses Artemisinin (HY-B0094) resistance by inhibiting and downregulating P-glycoprotein, and enhances the efficacy of Artemisinin. Chrysosplenetin promotes bone formation by activating the Wnt/β-catenin pathway and exerts anti-osteoporotic effects. | ||||||||||||||||||||
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Marionol | Marionol is a type of flavonol compound and belongs to the secondary metabolites of plants. Marionol exhibits significant specificity towards Cu²⁺ and possesses the characteristic of intramolecular proton transfer in excited state (ESIPT), enabling it to generate strong fluorescence upon excitation by ultraviolet light. The maximum excitation/emission wavelengths are 350 nm and 510 nm (depending on the solvent), respectively. Marionol can be used as a fluorescence probe for Cu²⁺. | |||||||||||||||||||||
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Artemetin acetate | Artemetin acetate is a Flavonoids product that can be isolated from the herbs of Achillea millefolium L.. | |||||||||||||||||||||
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Hexamethylquercetagetin | 98.0% | Hexamethylquercetagetin (Hexa-O-methylquercetagetin; Quercetagetin hexamethyl ether; 3,5,6,7,3',4'-Hexamethoxyflavone) is an orally active NF-κB inhibitor. Hexamethylquercetagetin inhibits NF-κB-derived luciferase activity, reduces phosphorylated p65 and IκBα, Cyclin D1, Bcl-2 and blocks TNFα-induced NF-κB activation. Hexamethylquercetagetin inhibits survival and proliferation of cervical carcinoma cells. Hexamethylquercetagetin suppresses tumor volume and weight in BALB/c nude mouse xenograft models of cervical carcinoma. Hexamethylquercetagetin can be used for the research of cancer, such as cervical carcinoma. | ||||||||||||||||||||
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Chrysosplenol D | 99.88% | Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities. | ||||||||||||||||||||
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3,5,7,3′,4′-Pentamethoxyflavone (Standard) | ≥98% | 3,5,7,3’,4’-Pentamethoxyflavone is a Ca2+ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases. | ||||||||||||||||||||
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References
- [1]. Ma CM, et al. Triterpenes and lignans from Artemisia caruifolia and their cytotoxic effects on meth-A and LLC tumor cell lines. Chem Pharm Bull (Tokyo). 2001 Feb;49(2):183-7. [Content Brief]
- [2]. Han X, et al. Development of an LC-MS/MS-based assay to determine artemitin in rat plasma and its application in a pharmacokinetic study. Biomed Chromatogr. 2018 Dec;32(12):e4356. [Content Brief]
- [3]. Qnais, Esam, et al. Antinociceptive effect of two flavonoids from Aloysia triphylla L. Jordan Journal of Biological Sciences 2.4 (2009): 167-170.
