Triterpenes and lignans from Artemisia caruifolia and their cytotoxic effects on meth-A and LLC tumor cell lines

  • Chem Pharm Bull (Tokyo). 2001 Feb;49(2):183-7. doi: 10.1248/cpb.49.183.
C M Ma  1 ,  N Nakamura ,  B S Min ,  M Hattori
Affiliations
  • 1. Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
PMID: 11217106 DOI: 10.1248/cpb.49.183
Abstract

One new triterpene, 3beta-hydroxy-29-norcycloart-24-one (1), and four new Lignans, caruilignans (2-5), together with six known compounds were isolated from the aerial part of Artemisia caruifolia BUCH.-HAM. ex TOXB. Their structures were determined by various spectroscopic means. Most of the isolated Lignans were moderately cytotoxic to Meth-A cells with ED50 values of 5-10 microg/ml, but not to Lowis lung carcinoma (LLC) cells. An oxime derivative of 1 showed more potent cytotoxic activity against Meth-A and LLC cells than the original triterpene 1.

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