Clausenidin
Clausenidin is a selective inhibitor targeting apoptosis-related pathways, including the mitochondrial pathway and death receptor pathway, and vascular endothelial growth factor (VEGF). Clausenidin induces mitochondrial membrane depolarization by activating caspase-3, caspase-8 and caspase-9, upregulating the pro-apoptotic protein Bax and downregulating the anti-apoptotic protein Bcl-2. Clausenidin also inhibits VEGF expression and blocks angiogenesis, exerting anti-tumor activity. Clausenidin has inhibitory effects against Mycobacterium tuberculosis (MIC=200 μg/mL). Clausenidin can induce apoptosis in liver cancer cells, arrest the cell cycle in the G2/M phase, and inhibit tumor angiogenesis. Clausenidin can be used in the research of malignant tumors such as liver cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 28384-44-3
- 分子式: C19H20O5
- 分子量:328.36
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
Caspase 3 |
Caspase-8 |
Caspase-9 |
化学情報
-
CAS 番号 28384-44-3
-
分子量 328.36
-
分子式 C19H20O5
-
SMILES
O=C1OC2=C(C(O)=C3C(CC(C)(C)OC3=C2C(C)(C)C=C)=O)C=C1
-
Structure Classification
-
Initial Source
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Sunthitikawinsakul A, et al. Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities. Planta Med. 2003 Feb;69(2):155-7. [Content Brief]
[2]. Waziri PM, et al. Clausenidin from Clausena excavata induces apoptosis in hepG2 cells via the mitochondrial pathway. J Ethnopharmacol. 2016 Dec 24;194:549-558. [Content Brief]
[3]. Waziri PM, et al. Clausenidin Induces Caspase 8-Dependent Apoptosis and Suppresses Production of VEGF in Liver Cancer Cells. Asian Pac J Cancer Prev. 2018 Apr 25;19(4):917-922. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Clausenidin 関連分類
HY-N16771 関連分類
Powered by Bioz