EEF1A2-IN-1

EEF1A2-IN-1 (compound 8e) (24-72 h) exhibits potent antiproliferative\ractivity against various cell lines, with IC₅₀ values of 0.73 (143B), 2.27 (SJSA-1), 4.34 (MG63), 2.47 (MNNG/HOS), 7.25 (U2OS), 1.93 (HOS), 4.84 (A549), and 9.59 μM (BMSC), respectively^[1].
EEF1A2-IN-1 (96 h-10 days) inhibits colony formation of 143B cells in an EEF1A2-dependent manner, also inhibits the proliferation of 143B cells, si-EEF1A2-2 cells, and OE-EEF1A2 143B cells with IC₅₀ values of 0.73, 2.78, and 0.19 μM, respectively, indicating that EEF1A2 is essential for the proliferation and migration of OS 143B cells^[1].
EEF1A2-IN-1 (0-3 μM, 0-24 h) effectively inhibits the migration of 143B cells^[1].
EEF1A2-IN-1 (0-3 μM) effectively inhibits the invasion of 143B cells^[1].
EEF1A2-IN-1 (0-3 μM) induces apoptosis in 143B cells by inhibiting its target EEF1A2, which results in the downregulation of both the Nogo-B protein and the AKT signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.