AKAP11 - A-kinase anchoring protein 11 Gene
Also Known as PRKA11; AKAP-11; AKAP220; PPP1R44
生物種: Homo sapiens
About AKAP11
This gene has 1 transcript (splice variant), 201 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 22.2), testis (RPKM 15.0) and 24 other tissues.
Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]
AKAP11 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_016248.4 | NP_057332.1 | A-kinase anchor protein 11 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
27484798 | GOA |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
A-kinase anchor protein 11 |
|
AKAP11 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
AKAP11 | Q9UKA4 | LITAF | Homo sapiens | Q99732 | 32814053 | |
|
Intra
|
AKAP11 | Q9UKA4 | LITAF | Homo sapiens | Q99732 | 32814053 | |
|
Intra
|
AKAP11 | Q9UKA4 | LITAF | Homo sapiens | Q99732 | 32814053 |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Retinitis Pigmentosa 48 |
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Canis familiaris | AKAP11 | VGNC | VGNC:37753 |
| Mus musculus | AKAP11 | MGD | MGI:2684060 |
| Bos taurus | AKAP11 | VGNC | VGNC:25781 |
| Felis catus | AKAP11 | VGNC | VGNC:59712 |
| Macaca mulatta | AKAP11 | VGNC | VGNC:69765 |
| Rattus norvegicus | AKAP11 | RGD | RGD:2079 |
| Others | AKAP11 | NCBI |