RAB21 - RAB21, member RAS oncogene family Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 23011

About RAB21

Cytogenetic location: 12q21.1 Genomic coordinates (GRCh38): 12:71,754,863-71,800,286 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 68 paralogues. Ubiquitous expression in kidney (RPKM 10.9), adrenal (RPKM 10.2) and 25 other tissues.

Summary

This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with Integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for Glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in Glioma tissues. [provided by RefSeq, Nov 2015]

RAB21 Products (1)

mRNA Protein Name
NM_014999.4 NP_055814.1 ras-related protein Rab-21

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables GDP binding IDA
IDA: Inferred from direct assay
16034420 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
16034420 GOA
enables GTP binding IMP
IMP: Inferred from mutant phenotype
15561770 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
16034420 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16525121 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in anterograde axonal transport IDA
IDA: Inferred from direct assay
22705394 GOA
involved in anterograde axonal transport IMP
IMP: Inferred from mutant phenotype
22705394 GOA
involved in positive regulation of early endosome to late endosome transport IMP
IMP: Inferred from mutant phenotype
15561770 GOA
involved in positive regulation of receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
15561770 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
31455601 GOA
involved in regulation of exocytosis IDA
IDA: Inferred from direct assay
22705394 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in Golgi cisterna membrane IDA
IDA: Inferred from direct assay
15561770 GOA
located in cytoplasmic side of early endosome membrane IDA
IDA: Inferred from direct assay
15561770 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
15561770 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
19745841 GOA
located in vesicle membrane IDA
IDA: Inferred from direct assay
15561770 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB21 Protein Structure

Ras

Ras: Ras family (21 - 181)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-21

  • GTP-binding protein RAB21

RAB21 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
RAB21 Q9UL25 APPL1 Homo sapiens Q9UKG1
Pull Down
17581628
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Carpenter Syndrome 1

  • Carpenter Syndrome

  • Acrocephalopolysyndactyly Type Ii

  • Acps Ii

  • CRPT1

  • Acrocephalopolysyndactyly Type 2

  • Acrocephalosyndactyly, Type Ii

  • Acrocephalopolysyndactyly 2

  • Acps2

  • Acps 2

  • Type Ii Acrocephalosyndactyly

  • Carpenter Syndrome, Type 1

  • Apert-Crouzon Disease
Charcot-Marie-Tooth Disease, Axonal, Type 2e

  • Charcot-Marie-Tooth Disease Type 2

  • CMT2E

  • CMT2S

  • CMT2Y

  • Charcot-Marie-Tooth Disease Type 2e

  • Charcot-Marie-Tooth Disease Type 2y

  • Charcot-Marie-Tooth Disease Axonal Type 2s

  • Charcot-Marie-Tooth Disease, Axonal, Type 2s

  • Charcot-Marie-Tooth Disease, Type 2e

  • Hereditary Motor And Sensory Neuropathy Type 2

  • Charcot-Marie-Tooth Neuropathy, Type 2s

  • Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s

  • Charcot-Marie-Tooth Disease, Axonal, Type 2y

  • Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y

  • Charcot-Marie-Tooth Neuropathy, Type 2y

  • Charcot-Marie-Tooth Disease, Type 2y

  • Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e

  • Charcot-Marie-Tooth Neuropathy Type 2e

  • Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation

  • Cmt2 Due To Vcp Mutation

  • Charcot-Marie-Tooth Disease Type 2s

  • Autosomal Dominant Charcot-Marie-Tooth Disease Type 2

  • Autosomal Dominant Axonal Charcot-Marie-Tooth Disease

  • Cmt2

  • Charcot-Marie-Tooth Neuropathy, Type 2e

  • Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type

  • Hereditary Motor And Sensory Neuropathy Okinawa Type

  • Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y

  • Charcot-Marie-Tooth Neuropathy Type 2y

  • Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s

  • Charcot-Marie-Tooth Neuropathy Type 2s

  • Charcot-Marie-Tooth Type 2

  • Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y

  • Charcot-Marie-Tooth Disease 2e

  • Charcot-Marie-Tooth Disease Axonal Type 2e

  • Charcot-Marie-Tooth Disease Neuronal Type 2e

  • Charcot-Marie-Tooth Disease 2s

  • Charcot-Marie-Tooth Neuropathy Axonal Type 2s

  • Charcot-Marie-Tooth Disease 2y

  • Charcot-Marie-Tooth Disease, Type 2

  • Hereditary Motor And Sensory-Neuropathy Type Ii
Charcot-Marie-Tooth Disease, Type 4b2

  • Charcot-Marie-Tooth Disease Type 4b2

  • CMT4B2

  • Charcot-Marie-Tooth Disease, With Focally Folded Myelin Sheaths, Autosomal Recessive, Type 4b2

  • Charcot-Marie-Tooth Neuropathy, Type 4b2

  • Charcot-Marie-Tooth Neuropathy Type 4b2

  • Autosomal Recessive Charcot-Marie-Tooth Disease With Focally Folded Myelin Sheaths Type 4b2

  • Cmt 4b2

  • Charcot Marie Tooth Disease Type 4b2

  • Charcot-Marie-Tooth Disease 4b2

  • Charcot-Marie-Tooth Disease Autosomal Recessive With Focally Folded Myelin Sheaths 4b2

  • Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4b2
Warburg Micro Syndrome 1

  • Warburg Micro Syndrome

  • Micro Syndrome

  • Warbm

  • WARBM1

  • Warburg Sjo Fledelius Syndrome

  • Warburg-Sjo-Fledelius Syndrome

  • Micro Syndrome 1

  • Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS22759 Rab21 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11531 RAB21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29273 Rab21 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus RAB21 VGNC VGNC:33628
Rattus norvegicus RAB21 RGD RGD:1303150
Macaca mulatta RAB21 VGNC VGNC:100097
Mus musculus RAB21 MGD MGI:894308
Canis familiaris RAB21 VGNC VGNC:45261
Others RAB21 NCBI