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KHNYN - KH and NYN domain containing Gene

Also Known as KIAA0323

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 23351

About KHNYN

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,423,165-24,441,843 (from NCBI)

This gene has 6 transcripts (splice variants), 100 orthologues and 6 paralogues. Ubiquitous expression in stomach (RPKM 18.8), small intestine (RPKM 18.4) and 25 other tissues.

Summary

The protein encoded by this gene contains a ribonuclease NYN domain and belongs to the N4BP1 family. The protein is a cofactor for the zinc finger Antiviral protein (ZAP protein) which targets viral RNA for degradation and restricts SARS-CoV-2 Infection. [provided by RefSeq, Sep 2021]

KHNYN Products (3)

mRNA	Protein	Name
NM_001290256.2	NP_001277185.1	protein KHNYN isoform 2
NM_001290257.2	NP_001277186.1	protein KHNYN isoform 1
NM_015299.3	NP_056114.1	protein KHNYN isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	30659753	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KHNYN Protein Structure

RNase_Zc3h12a

0
200
400
600
678 a.a.

Protein Preferred Names	Protein Names
protein KHNYN

KHNYN Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	KHNYN	O15037	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	KHNYN	O15037	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	KHNYN	O15037	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	KHNYN	O15037	NEDD8	Homo sapiens	Q15843	ITC	30659753
Intra	KHNYN	O15037	NEDD8	Homo sapiens	Q15843	Pull Down	30659753
Intra	KHNYN	O15037	NEDD8	Homo sapiens	Q15843	Anti Tag CoIP	30659753
Intra	KHNYN	O15037	NEDD8	Homo sapiens	Q15843	NMR	30659753
Intra	KHNYN	O15037	RNF216	Homo sapiens	Q9NWF9	Y2H Array	32296183
Intra	KHNYN	O15037	RNF216	Homo sapiens	Q9NWF9	Y2H Prey Pooling	32296183
Intra	KHNYN	O15037	RNF216	Homo sapiens	Q9NWF9	Validated Y2H	32296183
Intra	KHNYN	O15037	PLOD3	Homo sapiens	O60568	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS07241	KHNYN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	KHNYN	VGNC	VGNC:30544
Rattus norvegicus	KHNYN	RGD	RGD:1565688
Felis catus	KHNYN	VGNC	VGNC:63080
Canis familiaris	KHNYN	VGNC	VGNC:42339
Mus musculus	KHNYN	MGD	MGI:2451333
Macaca mulatta	KHNYN	VGNC	VGNC:73866
Others	KHNYN	NCBI