Mapk14 - mitogen-activated protein kinase 14 Gene

Also Known as p38; Crk1; Mxi2; p38a; CSBP2; Csbp1; PRKM14; PRKM15; p38MAPK; p38alpha; p38-alpha

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 26416

About Mapk14

Chromosome 17: 28,910,303-28,967,380 forward strand.GRCm39:CM001010.3

This gene has 10 transcripts (splice variants), 295 orthologues, 19 paralogues and is associated with 49 phenotypes. Ubiquitous expression in spleen adult (RPKM 35.2), thymus adult (RPKM 34.4) and 28 other tissues.

Summary

Enables MAP kinase activity and NFAT protein binding activity. Involved in several processes, including p38MAPK cascade; positive regulation of cell differentiation; and skeletal system development. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and positive regulation of cell differentiation. Located in several cellular components, including cytosol; mitochondrion; and spindle pole. Is active in glutamatergic synapse. Is expressed in several structures, including brain; early conceptus; epidermis; genitourinary system; and lung. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Apr 2022]

Mapk14 Products (5)

mRNA Protein Name
NM_011951.3 NP_036081.1 mitogen-activated protein kinase 14 isoform 1
NM_001168508.1 NP_001161980.1 mitogen-activated protein kinase 14 isoform 2
NM_001168513.1 NP_001161985.1 mitogen-activated protein kinase 14 isoform 3
NM_001168514.1 NP_001161986.1 mitogen-activated protein kinase 14 isoform 3
NM_001357724.1 NP_001344653.1 mitogen-activated protein kinase 14 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables MAP kinase activity IDA
IDA: Inferred from direct assay
7914033 MGI
enables MAP kinase activity IMP
IMP: Inferred from mutant phenotype
20551513 MGI
enables NFAT protein binding IPI
IPI: Inferred from physical interaction
15304486 MGI
enables kinase activity IDA
IDA: Inferred from direct assay
12808090 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10415025 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
10943842 MGI
enables protein serine/threonine kinase activity EXP
EXP: Inferred from Experiment
16364914 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18347059 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of D-glucose import IMP
IMP: Inferred from mutant phenotype
19403598 MGI
acts upstream of or within DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
12937170 MGI
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
20212154 MGI
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
20551513 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
10973481 MGI
involved in bone development IMP
IMP: Inferred from mutant phenotype
20551513 MGI
involved in cartilage condensation IMP
IMP: Inferred from mutant phenotype
17202865 MGI
acts upstream of or within cell morphogenesis IGI
IGI: Inferred from genetic interaction
17686994 MGI
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway IGI
IGI: Inferred from genetic interaction
18363966 MGI
acts upstream of or within cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
24349514 MGI
acts upstream of or within chondrocyte differentiation IDA
IDA: Inferred from direct assay
17644814 MGI
involved in chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17202865 MGI
acts upstream of or within fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
12802337 MGI
acts upstream of or within glucose metabolic process IMP
IMP: Inferred from mutant phenotype
12802337 MGI
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
7914033 MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway IDA
IDA: Inferred from direct assay
12872135 MGI
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
17202865 MGI
involved in osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
20551513 MGI
involved in osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
15304486 MGI
involved in p38MAPK cascade IDA
IDA: Inferred from direct assay
22847234 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
18347059 MGI
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
15304486 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
21768366 MGI
acts upstream of or within positive regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
19403598 MGI
acts upstream of or within positive regulation of brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
23977283 MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation IGI
IGI: Inferred from genetic interaction
21768366 MGI
acts upstream of or within positive regulation of erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
10943842 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22897442 MGI
involved in positive regulation of myoblast differentiation IMP
IMP: Inferred from mutant phenotype
22847234 MGI
involved in positive regulation of myoblast fusion IMP
IMP: Inferred from mutant phenotype
22847234 MGI
involved in positive regulation of myotube differentiation IMP
IMP: Inferred from mutant phenotype
22847234 MGI
acts upstream of or within positive regulation of protein import into nucleus IMP
IMP: Inferred from mutant phenotype
16954198 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10943842 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
15767678 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
15937334 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
20212154 MGI
acts upstream of or within regulation of ossification IDA
IDA: Inferred from direct assay
20053668 MGI
involved in regulation of synaptic membrane adhesion EXP
EXP: Inferred from Experiment
17988630 MGI
involved in regulation of synaptic membrane adhesion IDA
IDA: Inferred from direct assay
17988630 MGI
involved in regulation of synaptic membrane adhesion IEP
IEP: Inferred from expression pattern
17988630 MGI
involved in regulation of synaptic membrane adhesion IMP
IMP: Inferred from mutant phenotype
17988630 MGI
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22847234 MGI
involved in response to dietary excess IMP
IMP: Inferred from mutant phenotype
19948881 MGI
involved in response to insulin IMP
IMP: Inferred from mutant phenotype
19948881 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: Inferred from direct assay
12872135 MGI
acts upstream of or within response to muramyl dipeptide IDA
IDA: Inferred from direct assay
15692051 MGI
acts upstream of or within response to muscle stretch IMP
IMP: Inferred from mutant phenotype
19403598 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
15890335 MGI
acts upstream of or within stem cell differentiation IDA
IDA: Inferred from direct assay
17644814 MGI
acts upstream of or within striated muscle cell differentiation IGI
IGI: Inferred from genetic interaction
20160094 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10943842 MGI
acts upstream of or within positive effect tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
19948881 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
10601328 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
21976273 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11884367 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
17988630 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17988630 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
17988630 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17988630 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
11884367 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10601328 MGI
located in spindle pole IDA
IDA: Inferred from direct assay
15509711 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk14 Protein Structure

STKc_p38alpha

STKc_p38alpha: cd07877 (5 - 349)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 14

  • MAP kinase 14

  • MAP kinase p38 alpha

  • MAPK 14

  • mitogen-activated protein kinase p38 alpha

  • p38 MAP kinase alpha

  • p38 MAPK

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Phase
HY-10401 VX-702 Inhibitor 99.69% Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-N7922 Urolithin M5 Inhibitor 97.31% Unkown
HY-123961 SJF-8240 Degrader 99.33% Unkown
HY-18874 p38-α MAPK-IN-1 Inhibitor 99.71% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-RS08108 Mapk14 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08107 MAPK14 Human Pre-designed siRNA Set A / Unkown
HY-186241 NuP-3 Inhibitor / Unkown
HY-N18209 4-Hydroxy-3-butylphthalide / Unkown
HY-RS08109 Mapk14 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Mapk14 NCBI NCBI:1432