MAPK14 - mitogen-activated protein kinase 14 Gene

Also Known as RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1432

About MAPK14

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:36,027,808-36,124,214 (from NCBI)

This gene has 9 transcripts (splice variants), 292 orthologues and 19 paralogues. Ubiquitous expression in bone marrow (RPKM 18.5), placenta (RPKM 11.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

MAPK14 Products (18)

mRNA	Protein	Name
NM_139013.3	NP_620582.1	mitogen-activated protein kinase 14 isoform 3
XM_011514310.4	XP_011512612.2	mitogen-activated protein kinase 14 isoform X1
XM_047418236.1	XP_047274192.1	mitogen-activated protein kinase 14 isoform X8
NM_139014.3	NP_620583.1	mitogen-activated protein kinase 14 isoform 4
XR_007059211.1
NM_139012.3	NP_620581.1	mitogen-activated protein kinase 14 isoform 2
XM_047418234.1	XP_047274190.1	mitogen-activated protein kinase 14 isoform X4
XR_926065.3
XM_006714998.4	XP_006715061.1	mitogen-activated protein kinase 14 isoform X9
XR_007059210.1
XR_007059209.1
XM_047418237.1	XP_047274193.1	mitogen-activated protein kinase 14 isoform X9
NM_001315.3	NP_001306.1	mitogen-activated protein kinase 14 isoform 1
XM_047418235.1	XP_047274191.1	mitogen-activated protein kinase 14 isoform X5
XM_047418232.1	XP_047274188.1	mitogen-activated protein kinase 14 isoform X2
XM_017010300.3	XP_016865789.1	mitogen-activated protein kinase 14 isoform X6
XM_047418233.1	XP_047274189.1	mitogen-activated protein kinase 14 isoform X3
XM_017010299.3	XP_016865788.1	mitogen-activated protein kinase 14 isoform X7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables MAP kinase activity	IDA IDA: Inferred from direct assay	7997261	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23483889	GOA
enables mitogen-activated protein kinase p38 binding	IPI IPI: Inferred from physical interaction	11035004	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9788880	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	10391943	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	11532965	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	35857590	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to UV-B	IDA IDA: Inferred from direct assay	35857590	GOA
involved in cellular response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	20160708	GOA
acts upstream of or within cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	23776175	GOA
involved in cellular response to lipoteichoic acid	IMP IMP: Inferred from mutant phenotype	26649771	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IMP IMP: Inferred from mutant phenotype	18440775	GOA
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10838079	GOA
involved in negative regulation of hippo signaling	IMP IMP: Inferred from mutant phenotype	27402810	GOA
involved in p38MAPK cascade	IDA IDA: Inferred from direct assay	10330143	GOA
NOT involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	18440775	GOA
involved in positive regulation of cyclase activity	IMP IMP: Inferred from mutant phenotype	22027397	GOA
involved in positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	23483889	GOA
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	24299952	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	20160708	GOA
involved in regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	15251176	GOA
involved in signal transduction in response to DNA damage	IMP IMP: Inferred from mutant phenotype	20160708	GOA
involved in stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	35857590	GOA
involved in stress-activated protein kinase signaling cascade	IDA IDA: Inferred from direct assay	35857590	GOA
involved in stress-induced premature senescence	IMP IMP: Inferred from mutant phenotype	20160708	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18440775	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytosol	IDA IDA: Inferred from direct assay	7535770	GOA
located in nucleus	IDA IDA: Inferred from direct assay	30878395	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK14 Protein Structure

Pkinase

0
100
200
300
360 a.a.

Protein Preferred Names	Protein Names
mitogen-activated protein kinase 14	CSAID-binding protein MAP kinase 14 MAP kinase Mxi2 MAP kinase p38 alpha MAX-interacting protein 2 cytokine suppressive anti-inflammatory drug binding protein mitogen-activated protein kinase p38 alpha p38 MAP kinase p38 mitogen activated protein kinase p38alpha Exip stress-activated protein kinase 2A

MAPK14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAPK14	Q16539	DUSP7	Homo sapiens	Q16829	Anti Tag CoIP	33961781
Intra	MAPK14	Q16539	DUSP7	Homo sapiens	Q16829	Phosphatase Assay	9788880
Intra	MAPK14	Q16539	MAPKAPK3	Homo sapiens	Q16644	Y2H Array	31515488
Intra	MAPK14	Q16539	MAPKAPK3	Homo sapiens	Q16644	Anti Tag CoIP	25852190
Intra	MAPK14	Q16539	MAPKAPK3	Homo sapiens	Q16644	Anti Tag CoIP	33961781
Intra	MAPK14	Q16539	MAPKAPK3	Homo sapiens	Q16644	Anti Tag CoIP	26496610
Intra	MAPK14	Q16539	MAPKAPK3	Homo sapiens	Q16644	TAP	23602568
Intra	MAPK14	Q16539	MAPKAPK3	Homo sapiens	Q16644	TAP	23455922
Intra	MAPK14	Q16539	MAPKAPK3	Homo sapiens	Q16644	Anti Tag CoIP	31980649
Intra	MAPK14	Q16539	MAPKAPK3	Homo sapiens	Q16644	Pull Down	32707033
Intra	MAPK14	Q16539	MAPKAPK3	Homo sapiens	Q16644	Anti Tag CoIP	35271311
Intra	MAPK14	Q16539	MAPKAPK3	Homo sapiens	Q16644	PLA	25241761
Intra	MAPK14	Q16539	PTPRR	Homo sapiens	Q15256	Pull Down	10601328
Intra	MAPK14	Q16539	PTPRR	Homo sapiens	Q15256	IF	10601328
Intra	MAPK14	Q16539	MKNK2	Homo sapiens	Q9HBH9	Anti Tag CoIP	33961781
Intra	MAPK14	Q16539	MKNK2	Homo sapiens	Q9HBH9	TAP	23602568
Intra	MAPK14	Q16539	DUSP16	Homo sapiens	Q9BY84	Y2H Pooling	20936779
Intra	MAPK14	Q16539	ZNHIT1	Homo sapiens	O43257	Y2H	18624398
Intra	MAPK14	Q16539	ZNHIT1	Homo sapiens	O43257	Y2H	17380123
Intra	MAPK14	Q16539	ZNHIT1	Homo sapiens	O43257	Pull Down	17380123
Intra	MAPK14	Q16539	ZNHIT1	Homo sapiens	O43257	Protein Kinase Assay	17380123
Intra	MAPK14	Q16539	EEF1A1	Homo sapiens	P68104	Anti Tag CoIP	31980649
Intra	MAPK14	Q16539	DUSP9	Homo sapiens	Q99956	Pull Down	32707033
Intra	MAPK14	Q16539	DUSP9	Homo sapiens	Q99956	Anti Tag CoIP	33961781
Intra	MAPK14	Q16539	DUSP9	Homo sapiens	Q99956	Pull Down	21908610
Intra	MAPK14	Q16539	MAP2K6	Homo sapiens	P52564	Pull Down	32707033
Intra	MAPK14	Q16539	RB1	Homo sapiens	P06400	Protein Kinase Assay	20871633
Intra	MAPK14	Q16539	MAP2K3	Homo sapiens	P46734	Anti Tag CoIP	31980649
Intra	MAPK14	Q16539	MAP2K3	Homo sapiens	P46734	Pull Down	32707033
Intra	MAPK14	Q16539	MAP2K3	Homo sapiens	P46734	Anti Tag CoIP	17255949
Intra	MAPK14	Q16539	MAP2K3	Homo sapiens	P46734	Anti Tag CoIP	33961781
Intra	MAPK14	Q16539	MAP2K3	Homo sapiens	P46734	TAP	23602568
Intra	MAPK14	Q16539	ZFP36L1	Homo sapiens	Q07352	Pull Down	16189514
Intra	MAPK14	Q16539	MKNK1	Homo sapiens	Q9BUB5	Pull Down	32707033
Intra	MAPK14	Q16539	MKNK1	Homo sapiens	Q9BUB5	TAP	23602568
Intra	MAPK14	Q16539	MKNK1	Homo sapiens	Q9BUB5	Anti Tag CoIP	33961781
Intra	MAPK14	Q16539	MKNK1	Homo sapiens	Q9BUB5	Y2H Pooling	20936779
Intra	MAPK14	Q16539	MKNK1	Homo sapiens	Q9BUB5	TAP	23455922
Intra	MAPK14	Q16539	RPS6KA5	Homo sapiens	O75582	Anti Tag CoIP	33961781
Intra	MAPK14	Q16539	RPS6KA4	Homo sapiens	O75676	Anti Tag CoIP	33961781
Intra	MAPK14	Q16539	RPS6KA4	Homo sapiens	O75676	Y2H	9792677
Intra	MAPK14	Q16539	RPS6KA4	Homo sapiens	O75676	Anti Tag CoIP	9792677
Intra	MAPK14	Q16539	RPS6KA4	Homo sapiens	O75676	TAP	23602568
Intra	MAPK14	Q16539	RPS6KA4	Homo sapiens	O75676	Anti Tag CoIP	31980649
Intra	MAPK14	Q16539	RPS6KA4	Homo sapiens	O75676	Anti Tag CoIP	25852190
Intra	MAPK14	Q16539	MAPK3	Homo sapiens	P27361	Pull Down	11238443
Intra	MAPK14	Q16539	MAPK3	Homo sapiens	P27361	PLA	23397142
Intra	MAPK14	Q16539	CSNK1D	Homo sapiens	P48730-2	Validated Y2H	32814053
Intra	MAPK14	Q16539	CSNK1D	Homo sapiens	P48730-2	Y2H Array	32814053
Intra	MAPK14	Q16539	CSNK1D	Homo sapiens	P48730-2	Y2H Pooling	32814053
Intra	MAPK14	Q16539	SUPT20H	Homo sapiens	Q8NEM7	Y2H	21988832
Intra	MAPK14	Q16539	DUSP1	Homo sapiens	P28562	Y2H Pooling	20936779
Intra	MAPK14	Q16539	MAPKAPK2	Homo sapiens	P49137	Anti Tag CoIP	33961781
Intra	MAPK14	Q16539	MAPKAPK2	Homo sapiens	P49137	TAP	23602568
Intra	MAPK14	Q16539	MAPKAPK2	Homo sapiens	P49137	TAP	23455922
Intra	MAPK14	Q16539	MAPKAPK2	Homo sapiens	P49137	Anti Tag CoIP	31980649
Intra	MAPK14	Q16539	MAPKAPK2	Homo sapiens	P49137	Anti Tag CoIP	25852190
Intra	MAPK14	Q16539	MAPKAPK2	Homo sapiens	P49137	X-Ray Diffraction	17255097
Intra	MAPK14	Q16539	MAPKAPK2	Homo sapiens	P49137	Pull Down	32707033
Intra	MAPK14	Q16539	MAPKAPK2	Homo sapiens	P49137	Anti Tag CoIP	26496610
Intra	MAPK14	Q16539	MAPKAPK2	Homo sapiens	P49137	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAPK14 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73335	p38 alpha/MAPK14 Protein, Human (Active, sf9, His)	Q16539-2/NP_001306.1 (M1-S360)	≥ 85%, as determined by reducing SDS-PAGE.

MAPK14 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80213	p38 alpha/MAPK14 Antibody (YA706)	WB, ICC/IF, IHC-P	Human, Mouse
HY-P80776	p38 alpha/MAPK14 Antibody (YA696)	WB	Human, Mouse, Rat, Monkey
HY-P80776A	Phospho-p38 alpha/MAPK14 (Thr180+Tyr182) Antibody	WB, IHC-P, FC, ICC/IF, ELISA	Human, Mouse
HY-P80777	p38 alpha/MAPK14 Antibody (YA252)	WB, IP	Human
HY-P80777A	p38 alpha/MAPK14 Antibody (YA252)(PBS only)	WB, IP	Human
HY-P80842	Phospho-p38 alpha/MAPK14 (Thr180/Tyr182) Antibody	WB	Human, Mouse, Rat
HY-P80996	p38 alpha/MAPK14 Antibody (YA3534)	WB, ICC/IF	Human, Mouse, Rat
HY-P810544	Phospho-p38 (Thr180) Antibody (YA9813)	WB, ICC/IF, IHC-P	Human, Mouse, Rat
HY-P85712	p38 alpha/MAPK14 Antibody (YA5404)	WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86460	p38 alpha/MAPK14 Antibody (YA6152)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P89418	p38 MAPK Antibody (YA8861)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P89418A	p38 MAPK Antibody (YA8861)(PBS only)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Ischemia	Acute Coronary Syndrome
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Ureteral Obstruction
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Trichothiodystrophy 7, Nonphotosensitive	TTD7 Nonphotosensitive Trichothiodystrophy 7 Trichothiodystrophy 7, Non-Photosensitive
Spotted Fever	Spotted Fevers Spotted Fever Group Rickettsial Disease Tick-Borne Rickettsioses Tick-Borne Typhus Nos Rocky Mountain Spotted Fever Sao Paulo Fever Sao Paulo Typhus Lone Star Spotted Fever Colombian Spotted Fever American Spotted Fever Tick Typhus Due To Rickettsia Rickettsii Rocky Mountain Tick Fever Boutonneuse Fever Mediterranean Tick Fever Fièvre Boutonneuse Mediterranean Spotted Fever Tick Typhus Due To Rickettsia Conorii African Tick Typhus Indian Tick Typhus Kenya Tick Typhus North Asian Tick Fever Siberian Tick Typhus Tick Typhus Due To Rickettsia Siberica North Asian Spotted Fever Queensland Tick Typhus Queensland Fever
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Cardiomyopathy, Familial Hypertrophic, 25	Hypertrophic Cardiomyopathy 25 CMH25 Cardiomyopathy, Hypertrophic, 25 Cardiomyopathy Familial Hypertrophic 25 Cardiomyopathy, Familial Hypertrophic 25 Cardiomyopathy, Hypertrophic, Type 25
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Alexander Disease	Alexander'S Disease ALXDRD Alexanders Leukodystrophy Axd Megalencephaly In Infancy Accompanied By Progressive Spasticity And Dementia Alx Demyelinogenic Leukodystrophy Dysmyelinogenic Leukodystrophy Fibrinoid Degeneration Of Astrocytes Leukodystrophy With Rosenthal Fibers Alexander Disease Type Ii Axd Type Ii Alexander Disease Type I Axd Type I Alexanders Disease Alexander'S Leukodystrophy
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Congenital Anomaly Of Heart Heart Defect Heart Malformation Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Proteasome-Associated Autoinflammatory Syndrome 1	Jmp Syndrome Nakajo-Nishimura Syndrome Nkjo Autoinflammation, Lipodystrophy, And Dermatosis Syndrome Proteasome-Associated Autoinflammatory Syndrome 1 And Digenic Forms Nakajo Syndrome PRAAS1 Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy And Elevated Temperature Syndrome Candle Joint Contractures, Muscular Atrophy, Microcytic Anemia, And Panniculitis-Induced Lipodystrophy Aldd Joint Contractures - Muscle Atrophy - Microcytic Anemia - Panniculitis-Induced Lipodystrophy Nakajo Nishimura Syndrome Amyotrophy Fat Tissue Anomaly Japanese Autoinflammatory Syndrome With Lipodystrophy Jasl Joint Contractures Muscular Atrophy Microcytic Anemia And Panniculitis-Induced Lipodystrophy Nns Nodular Erythema With Digital Changes Secondary Hypertrophic Osteoperiostosis With Pernio Inflammation
Glioma
Glioblastoma Mesenchymal Subtype
Anthrax Disease	Anthrax Ragpicker'S Disease Black Baine Malignant Edema Malignant Pustule Siberian Plague Wool Sorter'S Disease Gas Gangrene Cutaneous Anthrax Anthrax Infection Splenic Fever
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Chlamydia	Chlamydial Infection Chlamydia Trachomatis Infectious Disease Chlamydial Disease Chlamydia Infections
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Disease, Susceptibility To Coronary Artery Anomaly Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10401	VX-702	Inhibitor	99.69%	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N7922	Urolithin M5	Inhibitor	97.31%	Unkown
HY-123961	SJF-8240	Degrader	99.33%	Unkown
HY-18874	p38-α MAPK-IN-1	Inhibitor	99.71%	Unkown
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		96.07%	Unkown
HY-RS08108	Mapk14 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08107	MAPK14 Human Pre-designed siRNA Set A		/	Unkown
HY-186241	NuP-3	Inhibitor	/	Unkown
HY-N18209	4-Hydroxy-3-butylphthalide		/	Unkown
HY-RS08109	Mapk14 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAPK14	RGD	RGD:70496
Mus musculus	MAPK14	MGD	MGI:1346865
Canis familiaris	MAPK14	VGNC	VGNC:42995
Bos taurus	MAPK14	VGNC	VGNC:31216
Felis catus	MAPK14	VGNC	VGNC:68167
Macaca mulatta	MAPK14	VGNC	VGNC:74645
Others	MAPK14	NCBI