RPS6KA4 - ribosomal protein S6 kinase A4 Gene

Also Known as MSK2; RSK-B; S6K-alpha-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8986

About RPS6KA4

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,359,162-64,372,215 (from NCBI)

This gene has 8 transcripts (splice variants), 190 orthologues and 7 paralogues. Ubiquitous expression in spleen (RPKM 12.2), colon (RPKM 9.2) and 25 other tissues.

Summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

RPS6KA4 Products (4)

mRNA	Protein	Name
NM_001006944.2	NP_001006945.1	ribosomal protein S6 kinase alpha-4 isoform b
NM_001300802.2	NP_001287731.1	ribosomal protein S6 kinase alpha-4 isoform c
NM_001318361.2	NP_001305290.1	ribosomal protein S6 kinase alpha-4 isoform d
NM_003942.3	NP_003933.1	ribosomal protein S6 kinase alpha-4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	9792677	GOA
enables histone H3S10 kinase activity	IMP IMP: Inferred from mutant phenotype	12773393	GOA
enables histone H3S28 kinase activity	IMP IMP: Inferred from mutant phenotype	12773393	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9792677	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9792677	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in interleukin-1-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20018936	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	9792677	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20018936	GOA
involved in post-translational protein modification	IMP IMP: Inferred from mutant phenotype	12773393	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9792677	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9792677	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	9792677	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS6KA4 Protein Structure

Pkinase

Pkinase_C

Pkinase

0
200
400
600
772 a.a.

Protein Preferred Names	Protein Names
ribosomal protein S6 kinase alpha-4	90 kDa ribosomal protein S6 kinase 4

RPS6KA4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPS6KA4	O75676	MAPK14	Homo sapiens	Q16539	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Coffin-Lowry Syndrome	CLS Coffin Syndrome 1 Coffin Syndrome Intellectual Disability With Osteocartilaginous Abnormalities Dwarfism, Lean Spastic Type Lean Spastic Dwarfism Mental Retardation With Osteocartilaginous Abnormalities Coffin Lowry Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148065	FMF-06-098-1	Inhibitor	98.77%	Unkown
HY-RS12257	RPS6KA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22025	Rps6ka4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28543	Rps6ka4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RPS6KA4	RGD	RGD:1307277
Felis catus	RPS6KA4	VGNC	VGNC:64757
Canis familiaris	RPS6KA4	VGNC	VGNC:45741
Macaca mulatta	RPS6KA4	VGNC	VGNC:76930
Mus musculus	RPS6KA4	MGD	MGI:1930076
Bos taurus	RPS6KA4	VGNC	VGNC:34143
Others	RPS6KA4	NCBI