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Cat. No.: HY-N21965

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Thesinine

Thesinine is a saturated pyrrolizidine alkaloid isolated from the seeds and flowers of *Borago officinalis*; it is the primary alkaloid in borage seeds and the only alkaloid present in borage flowers. In silico predictions indicate that Thesinine binds to the AKT1, MAPK3, MMP9, and MAPK14 proteins. Thesinine is applicable to research related to skin aging

For research use only. We do not sell to patients.

CAS No.: 488-02-8
Formula: C₁₇H₂₁NO₃
Molecular Weight:287.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Thesinine Chemical Structure

CAS No.: 488-02-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Akt1

MMP9

MAPK3

MAPK14

All Akt Isoforms :

All p38 MAPK Isoforms :

All MMP Isoforms :

In Vitro

Thesinine forms energetically favorable interactions with human AKT1 (allosteric site), MAPK3, MMP9, and MAPK14 proteins, among which it exhibits the highest binding affinity for AKT1 (allosteric site)^[1].
Thesinine forms stable and persistent interactions with human AKT1 (allosteric site) and MMP9 proteins during 100 ns molecular dynamics simulations, but its binding stability with human MAPK14 is reduced^[1].
Thesinine is the sole alkaloid in the flowers of borage (Borago officinalis) and also the major alkaloid in mature seeds^[2].
Thesinine is the only detected alkaloid in a batch of immature seeds, while it is not detected in any of the three seed oil samples^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 488-02-8
Molecular Weight 287.35
Formula C₁₇H₂₁NO₃
SMILES

OC(C=C1)=CC=C1/C=C/C(OC[C@H]2[C@]3([H])N(CCC3)CC2)=O
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cho MH, et al. An Integrated Systems Pharmacology Approach Combining Bioinformatics, Untargeted Metabolomics and Molecular Dynamics to Unveil the Anti-Aging Mechanisms of Tephroseris flammea. Biomolecules. 2025 Dec 15;15(12):1740.

[2]. Dodson C D, et al. Pyrrolizidine alkaloids from borage (Borago officinalis) seeds and flowers[J]. Journal of Natural products, 1986, 49(4): 727-728.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Thesinine

All Akt Isoforms

All p38 MAPK Isoforms

All MMP Isoforms