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Cat. No.: HY-N21965

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Thesinine

Thesinine is a saturated pyrrolizidine alkaloid and the primary alkaloid found in the seeds and flowers of Borago officinalis. Thesinine binds to AKT1, MAPK3, MMP9, and MAPK14 proteins as predicted by in silico analysis. Thesinine is applicable to research related to skin aging

For research use only. We do not sell to patients.

CAS No.: 488-02-8
Formula: C₁₇H₂₁NO₃
Molecular Weight:287.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Thesinine Chemical Structure

CAS No.: 488-02-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Biological Activity

Description

IC₅₀ & Target

^[1]

Akt1

MMP9

MAPK3

MAPK14

All Akt Isoforms :

All MMP Isoforms :

In Vitro

Thesinine forms energetically favorable interactions with human AKT1 (allosteric site), MAPK3, MMP9, and MAPK14 proteins, among which it exhibits the highest binding affinity for AKT1 (allosteric site)^[1].
Thesinine forms stable and persistent interactions with human AKT1 (allosteric site) and MMP9 proteins during 100 ns molecular dynamics simulations, but its binding stability with human MAPK14 is reduced^[1].
Thesinine is the sole alkaloid in the flowers of borage (Borago officinalis) and also the major alkaloid in mature seeds^[2].
Thesinine is the only detected alkaloid in a batch of immature seeds, while it is not detected in any of the three seed oil samples^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 488-02-8
Molecular Weight 287.35
Formula C₁₇H₂₁NO₃
SMILES

OC(C=C1)=CC=C1/C=C/C(OC[C@H]2[C@]3([H])N(CCC3)CC2)=O
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cho MH, et al. An Integrated Systems Pharmacology Approach Combining Bioinformatics, Untargeted Metabolomics and Molecular Dynamics to Unveil the Anti-Aging Mechanisms of Tephroseris flammea. Biomolecules. 2025 Dec 15;15(12):1740. [Content Brief]

[2]. Dodson C D, et al. Pyrrolizidine alkaloids from borage (Borago officinalis) seeds and flowers[J]. Journal of Natural products, 1986, 49(4): 727-728.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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Thesinine

All Akt Isoforms

All MMP Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Thesinine Related Classifications

HY-N21965 Related Classifications

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