DBR1 - debranching RNA lariats 1 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 51163

About DBR1

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:138,160,988-138,174,921 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and is associated with 1 phenotype. Ubiquitous expression in stomach (RPKM 5.7), bone marrow (RPKM 5.2) and 25 other tissues.

Summary

The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]

DBR1 Products (1)

mRNA Protein Name
NM_016216.4 NP_057300.2 lariat debranching enzyme

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables RNA lariat debranching enzyme activity IMP
IMP: Inferred from mutant phenotype
10982890 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in RNA fragment catabolic process IMP
IMP: Inferred from mutant phenotype
37656279 GOA
involved in RNA splicing, via transesterification reactions IMP
IMP: Inferred from mutant phenotype
10982890 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in nucleus IDA
IDA: Inferred from direct assay
10982890 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DBR1 Protein Structure

Metallophos

Metallophos: Calcineurin-like phosphoesterase (1 - 229)

DBR1

DBR1: Lariat debranching enzyme, C-terminal domain (243 - 377)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 544 a.a.
Protein Preferred Names Protein Names

lariat debranching enzyme

  • RNA lariat debranching enzyme

関連疾患

Diseases Alias
Encephalitis, Acute, Infection -Induced 11

  • IIAE11

  • Encephalitis, Acute, Infection -Induced, Susceptibility To, 11

  • Encephalitis, Acute, Infection -Induced, 11
Viral Encephalitis

  • Epidemic Encephalitis

  • Encephalitis Viral

  • Encephalitis, Arbovirus

  • Arbovirus Encephalitis

  • Postviral Encephalitis Nos

  • Equine Encephalitis

  • Tick-Borne Encephalitis

  • Viral Encephalitis Transmitted By Tick

  • Mosquito-Borne Encephalitis

  • Acute Haemorrhagic Encephalitis

  • Acute Idiopathic Encephalitis

  • Chronic Viral Encephalitis

  • Endemic Encephalitis

  • Subacute Viral Encephalitis

  • Viral Haemorrhagic Encephalitis

  • Viral Nonepidemic Encephalitis

  • Nonepidemic Encephalitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-156744 DBr-1 Degrader 98.87% Unkown
HY-RS03553 DBR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus DBR1 VGNC VGNC:61350
Macaca mulatta DBR1 VGNC VGNC:71626
Rattus norvegicus DBR1 RGD RGD:1598038
Bos taurus DBR1 VGNC VGNC:27895
Canis familiaris DBR1 VGNC VGNC:39786
Mus musculus DBR1 MGD MGI:1931520
Others DBR1 NCBI